Observational studyTransfusion2026
Whole blood resuscitation and post-traumatic organ dysfunction in injured children.
Observational study in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundBoth whole blood (WB) and component therapy (CT) are used for hemostatic resuscitation in injured children. We hypothesize that early WB transfusion compared to CT alone is associated with decreased post-traumatic organ dysfunction. STUDY DESIGN AND
methodsThis single-center observational study included children ages 0-17 years between January 2021 and March 2024 with trauma mechanism and intensive care unit admission. The primary outcome was Pediatric Logistic Organ Dysfunction 2 (PELOD-2) score on post-trauma days 1-7. Data were analyzed using linear regression adjusting for age, sex, race, year, injury mechanism, injury severity score (ISS), shock index pediatric age-adjusted, and total 4-h transfusion volume (mL/kg).
resultsIn total, 540 subjects met eligibility criteria; of the 52/540 (10%) who received blood transfusion within 4 h, 11/52 (21%) received RBC alone, 12/52 (23%) received WB alone, 9/52 (17%) of subjects received RBC plus other, and 20/52 (38%) received WB plus other. The cohort was 60% (326/540) male, 83% (449/540) blunt injury mechanism, median (interquartile range [IQR]) age 3 years (0-11), and median (IQR) ISS of 11 (8-18). In adjusted analysis, transfusion of WB + other was an independent predictor of lower PELOD-2 score through post-trauma day 7 in comparison to subjects receiving RBC + other. DISCUSSION: In subjects who were transfused multiple blood products, receipt of any WB versus CT alone for hemostatic resuscitation after injury was associated with reduced organ dysfunction. Further investigation is needed in large cohorts to fully elucidate clinical benefit and improve mechanistic understanding.
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