Evidence map›Paper›PMID 41821639›Full record

ArticleCardiology research and practice2026

Synergistic Effects of Compound Dendrobium Candidum and Antihypertensive Medications on Refractory Hypertension in Spontaneously Hypertensive Rats.

Xiaoyu Chen, Cheng Tong, Jie Wang, Yue Wu, Tuo Feng, Jing Wang, Zedong Gong, Yingzhi Chen, Shiyong Chen, Xiaoming Jin and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xiaoyu ChenSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China, zcmu.edu.cn.
Cheng TongLinping Campus, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, z2hospital.com.
Jie WangSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China, zcmu.edu.cn.
Yue WuZhejiang Academy of Traditional Chinese Medicine, Hangzhou, China, zcmu.edu.cn.
Tuo FengZhejiang Academy of Traditional Chinese Medicine, Hangzhou, China, zcmu.edu.cn.
Jing WangSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China, zcmu.edu.cn.
Zedong GongSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China, zcmu.edu.cn.
Yingzhi ChenSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China, zcmu.edu.cn.
Shiyong ChenSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China, zcmu.edu.cn.
Xiaoming JinStark Neuroscience Research Institute and Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA, indiana.edu.
Sisi ChenZhejiang Academy of Traditional Chinese Medicine, Hangzhou, China, zcmu.edu.cn.
Zhongxiu GuoZhejiang Academy of Traditional Chinese Medicine, Hangzhou, China, zcmu.edu.cn.ORCID https://orcid.org/0009-0004-6007-958X
Xuan ChenZhejiang Academy of Traditional Chinese Medicine, Hangzhou, China, zcmu.edu.cn.
Zeming RenZhejiang Academy of Traditional Chinese Medicine, Hangzhou, China, zcmu.edu.cn.
Guanhai DaiZhejiang Academy of Traditional Chinese Medicine, Hangzhou, China, zcmu.edu.cn.
Yeling TongZhejiang Academy of Traditional Chinese Medicine, Hangzhou, China, zcmu.edu.cn.
Xiyu MeiZhejiang Academy of Traditional Chinese Medicine, Hangzhou, China, zcmu.edu.cn.
Renzhao WuZhejiang Academy of Traditional Chinese Medicine, Hangzhou, China, zcmu.edu.cn.ORCID https://orcid.org/0000-0002-4140-9887
Xiaomin XueSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China, zcmu.edu.cn.ORCID https://orcid.org/0000-0002-5166-1146

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Compound dendrobium candidum (CDC) is formulated from Methods: SHRs were treated with either CDC alone or CDC combined with two or three antihypertensive agents including irbesartan, amlodipine, or terazosin, for a duration of 6 weeks. The alterations in blood pressure, angiotensin II (Ang II), insulin, blood sugar, angiotensin II type I receptor (AT Results: In comparison to the findings observed in the irbesartan + amlodipine + terazosin (IAT) group, the addition of CDC significantly enhanced antihypertensive efficacy. The rate of achieving blood pressure targets (< 150 mmHg) in SHRs with refractory hypertension increased from 0% to 100%. Treatment with CDC significantly reduced the compensatory increase in AT Conclusions: CDC in combination with antihypertensive drugs showed a synergistic effect in controlling refractory hypertension. The mechanism of action may be related to the attenuation of excessive expression of AT

Indexed as

angiotensinangiotensin II typeII receptorscompound dendrobium candidumrefractory hypertensionspontaneously hypertensive rat

Identifiers

PMID41821639
PMCPMC12977149

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.