ArticleImaging neuroscience (Cambridge, Mass.)
TRAMFIX: TRavelling Across Melbourne for FIXel-based analysis (a reproducibility and reliability study).
Article in Imaging neuroscience (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Fixel-based analysis (FBA) has gained substantial interest for its ability to probe fibre-specific changes in the brain's white matter from diffusion-weighted imaging data. However, the reproducibility and reliability of fixel-based measures across different scanners remains largely unknown. In this work, we present TRAMFIX (TRavelling Across Melbourne for FIXel-based analysis): a multisite dataset of traveling participants (n = 10 healthy adults) scanned across four 3T MRI scanners using a harmonised multi-shell diffusion-weighted imaging (DWI) protocol. DWI data were processed using two pipelines that can be adopted when performing multi-site FBA studies (site-specific vs. pooled processing). We extracted fixel-based measures of fibre density (FD), fibre cross-section (FC), and fibre density and cross-section (FDC) from the harmonized protocol. While the primary goal was to assess reproducibility and reliability of FBA metrics, we additionally computed diffusion tensor imaging (DTI)-based fractional anisotropy (FA) and mean diffusivity (MD) for the purposes of comparison with previous studies. Within-subject coefficients of variation (CV
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