ArticleThe EPMA journal2026
Innovative mitochondria-based holistic 3PM approach to female health status: Facts and outlook.
Article in The EPMA journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Evidence-based recommendations for advancing the chronic pelvic pain syndrome management by the paradigm change from reactive symptom suppression to proactive 3PM-guided patient-centered care.The EPMA journal · 2026Review
- The specificity trap in routine tumor biomarker interpretation: Advancing the 3PM-based clinical decision framework to benefits of patients.The EPMA journal · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Throughout a woman's life, energy metabolism faces more volatile demands compared to men, driven by major hormonal transitions like puberty, the menstrual cycle, pregnancy, and menopause. Mitochondria, as central organelles for energy production and vital cellular biosensors, are consequently subjected to substantial physiological stress. When the body's compensatory mechanisms are overwhelmed, particularly in states of suboptimal health, compromised mitochondrial functionality is characterised by increased generation of reactive oxygen species (ROS) frequently associated with a chronification of the low-grade inflammation and development of follow-up pathologies. Compromised health and shifted homeostasis of mitochondria are crucial for development and progression of a broad spectrum of disorders in female subpopulations which can be exemplified by chronic fatigue, gestational diabetes mellitus, preeclampsia, polycystic ovary syndrome, and gynaecologic cancers, amongst others. This article strongly advocates for the implementation of an innovative, mitochondria-based holistic approach within the framework of Predictive, Preventive, and Personalised Medicine (3PM). 3PM-guided strategy focuses on the early detection of reversible health damage shifting care from reactive treatment to individualised proactive, risk-adapted management of the health conditions. The integration and interpretation of the multimodal data, supported by artificial intelligence, enable the stratification of individuals in suboptimal health conditions and affected patients for cost-effective protective measures tailored to individualised patient profiles, therapeutic interventions, and personalised pre- and rehabilitation programmes. In summary, by utilising mitochondrial biosensorics for monitoring systemic effects in a holistic manner, the presented 3PM-guided innovation offers a robust model for protecting individuals against health-to-disease transition and disease progression in affected patient cohorts.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.