ReviewFrontiers in cell and developmental biology2026
PDGF signaling in cartilage regeneration: molecular mechanisms and cellular effects.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Cartilage damage has long been a challenge in regenerative medicine research, due to the avascular nature of cartilage tissue and its intrinsically limited reparative capacity. In recent years, more and more studies have found that the regulation of signaling factors at the temporal, spatial, and dose levels is one of the key factors restricting the effective regeneration of cartilage. As a classic growth factor, platelet-derived growth factor (PDGF) plays an important regulatory role in cell recruitment, proliferation, and tissue repair, and has gradually become the focus of cartilage regeneration research. Evidence has shown that PDGF exhibits significant context-dependent regulatory characteristics in different microenvironments. This review systematically reviews the structural characteristics and signal transduction pathways of different PDGF isoforms and their receptors (PDGFR-α and PDGFR-β), focusing on their biological roles at the cellular level, including the regulation of mesenchymal stem cell migration and expansion, the impact on chondrocyte survival and metabolic activity, and their bidirectional regulatory effects in the synovium-cartilage axis and osteoarthritis-related microenvironment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.