Evidence map›Paper›PMID 41822467›Full record

ArticleSmall science2026

Graphene Triggers Inflammation in Murine Microglia via Phagocytosis.

Pratika Rai, Robert Subirana Slotos, Ahmar Hasnain, Emma Walter, Marina Mantellatto Grigoli, Irini Petrou, Mario Dejung, Jia-Xuan Chen, Oliver Tüscher, Alexey Tarasov and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pratika RaiFaculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences Zweibrücken Germany.
Robert Subirana SlotosDepartment of Psychiatry and Psychotherapy University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.
Ahmar HasnainFaculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences Zweibrücken Germany.
Emma WalterDepartment of Psychiatry and Psychotherapy University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.
Marina Mantellatto GrigoliFaculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences Zweibrücken Germany.
Irini PetrouFaculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences Zweibrücken Germany.
Mario DejungInstitute of Molecular Biology Mainz Germany.
Jia-Xuan ChenInstitute of Molecular Biology Mainz Germany.
Oliver TüscherDepartment of Psychiatry and Psychotherapy University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.
Alexey TarasovFaculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences Zweibrücken Germany.ORCID https://orcid.org/0009-0007-9109-619X
Kristina EndresFaculty of Computer Sciences and Microsystems Technology Kaiserslautern University of Applied Sciences Zweibrücken Germany.ORCID https://orcid.org/0000-0002-1099-8287

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graphene and related materials are increasingly used in biomedical technologies, including neural interfaces, but their impact on brain immune cells remains poorly understood. The present study investigates the acute response of murine microglial SIM-A9 cells to single-layer graphene, with carbon nanotubes and graphene nanoplatelets included as comparative controls. Short-term culture for 3 h on graphene-coated substrates did not induce cytotoxicity but promoted inflammatory activation, reflected in increased release of the cytokine tumor necrosis factor alpha (TNF-

Indexed as

carbon nanotubesgraphene nanoplateletsmicrogliaproteomicssingle‐layer graphene

Identifiers

PMID41822467
PMCPMC12977177

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.