Evidence map›Paper›PMID 41822513›Full record

ArticleFrontiers in immunology2026

Eccentric treadmill training and skeletal muscle immunometabolic responses in HFD-induced insulin resistance.

Wei Luo, Yuanyuan Wang, Siyi He, Shijin Zhao, Yue Zhou, Lei Ai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei LuoSchool of Sport and Health, Nanjing Sport Institute, Nanjing, China.
Yuanyuan WangSchool of Sport and Health, Nanjing Sport Institute, Nanjing, China.
Siyi HeSchool of Sport and Health, Nanjing Sport Institute, Nanjing, China.
Shijin ZhaoSchool of Sport and Health, Nanjing Sport Institute, Nanjing, China.
Yue ZhouSchool of Kinesiology, Beijing Sport University, Beijing, China.
Lei AiResearch Center for Kinesiology, Jiangsu Research Institute of Sports Science, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In recent years, repeated eccentric exercise has gained increasing attention as a potentially superior intervention for ameliorating insulin resistance (IR). However, the underlying mechanisms responsible for these effects remain incompletely understood. This study aims to investigate the effects and underlying mechanisms of moderate-intensity eccentric treadmill training on skeletal muscle IR. Methods: A mouse model of IR was established using a high-fat diet (HFD) for 12 weeks, followed by an 8-week eccentric treadmill training. Results: HFD-induced IR led to elevated pro-inflammatory factors and reduced GLUT4, F4/80 & phospho-AKT (Ser Conclusion: Moderate-intensity eccentric treadmill training ameliorates HFD-induced skeletal muscle IR, likely driven by AKT-mediated reduction in pro-inflammatory M1 macrophage polarization.

Indexed as

Diet, High-FatInsulin ResistanceMuscle, SkeletalPhysical Conditioning, AnimalAnimalsCytokinesDisease Models, AnimalGlucoseMacrophagesMaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-aktRAW 264.7 CellsCytokinesGlucoseProto-Oncogene Proteins c-aktAKT signaleccentric exerciseinsulin resistancemacrophagesskeletal muscle

Identifiers

PMID41822513
PMCPMC12975572

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.