Evidence map›Paper›PMID 41822778›Full record

ArticleRSC advances2026

Lonidamine-1,3,4-oxadiazole derivatives with antiproliferative effects on HCT116 colon cancer cell lines: biological evaluation, ADMET, and computational studies.

Raveendra Madhukar Bhat, A N Priyadarshini, M S Sudhanva, Gangadhar V Muddapur, Kawthar Alhussieni, Raman Kumar K, Rangappa S Keri

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Raveendra Madhukar BhatCentre for Nano and Material Sciences, Jain (Deemed-to-be University) Jain Global Campus, Jakkasandra Post, Kanakapura Road, Ramanagara District Bangalore Karnataka 562112 India sk.rangappa@jainuniversity.ac.in keriphd@gmail.com +918027577199 +919620667075.
A N PriyadarshiniAdichunchanagiri Institute for Molecular Medicine, Adichunchanagiri Institute of Medical Sciences, Adichunchanagiri University BG Nagara-571448 Karnataka India.
M S SudhanvaAdichunchanagiri Institute for Molecular Medicine, Adichunchanagiri Institute of Medical Sciences, Adichunchanagiri University BG Nagara-571448 Karnataka India.
Gangadhar V MuddapurDepartment of Physics, KLE Technological University Hubballi-580031 Karnataka India.
Kawthar AlhussieniDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Malaya Kuala Lumpur 50603 Malaysia.
Raman Kumar KAurigene Pharmaceutical Services Bangalore Karnataka India.
Rangappa S KeriCentre for Nano and Material Sciences, Jain (Deemed-to-be University) Jain Global Campus, Jakkasandra Post, Kanakapura Road, Ramanagara District Bangalore Karnataka 562112 India sk.rangappa@jainuniversity.ac.in keriphd@gmail.com +918027577199 +919620667075.ORCID https://orcid.org/0000-0001-6262-8379

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, cancer has emerged as a significant challenge for healthcare systems, posing challenges to researchers to develop new treatments. Among various cancers, colorectal cancer is a major cause of death worldwide. To develop novel compounds that strongly inhibit colon cancer cells, lonidamine-1,3,4-oxadiazole derivatives 7(a-h) were designed and synthesized. The prepared compounds were characterized by various spectral techniques, including NMR (

Identifiers

PMID41822778
PMCPMC12977971

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.