ArticleRSC advances2026
Context-dependent cytotoxicity and ADMET profiling of methoxylated flavonoids as novel leads for metastatic prostate cancer.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Molecular Profiling and Selective Pro-Apoptotic Activity of a Pruning-DerivedInternational journal of molecular sciences · 2026Article
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Authors and funding
1 author.
Funding
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Abstract
Prostate cancer continues to be a leading cause of cancer-related mortality among men. Acquired resistance to currently available treatment options necessitates discovery of novel bioactive scaffolds. Flavonoids, a group of plant-derived polyphenolic compounds, have been shown to interfere with cellular mechanisms such as mitochondrial functioning, cell-cycle progression and apoptotic cell death. The current study assessed the cytotoxic activity, cellular uptake and apoptosis-inducing properties of six structurally diverse methoxylated flavonoids isolated from Varthemia iphionoides, namely jaceidin (V1), kumatakenin (V2), 4'-hydroxy-3,5,6,7-tetramethoxyflavone (V3), santin (V4), quercetin-3,3'-dimethyl ether (V5) and 6-methoxyisokaempferide (V6) in metastatic prostate cancer cell lines PC3 and DU145. The cytotoxic activity of these compounds was assessed using MTT assay and the apoptosis, mitochondrial membrane potential and cell-cycle phases were analyzed employing flow cytometry-based assays. Flavonoids V3, V5 and V6 demonstrated the most promising cytotoxic activities among the series. Compound V3 exhibited IC50 values of 7.22 ± 0.21 µM and 1.30 ± 0.69 µM, V5 of 5.16 ± 0.13 µM and 28.17 ± 2.74 µM, while V6 showed 1.67 ± 0.87 µM and 1.90 ± 0.88 µM in PC3 and DU145 cell lines respectively. Flavonoid V3 mediated perturbation of cell-cycle dynamics was cell line specific
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Registered trials
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