Evidence map›Paper›PMID 41823267›Full record

ArticleRNA biology2026

Role of small intronic RNAs in the crosstalk between immune cells and β-cells during type 1 diabetes development.

Shagun Poddar, Flora Brozzi, Cristina Cosentino, Cécile Jacovetti, Claudiane Guay, Jérôme Perrard, Romano Regazzi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shagun PoddarDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Flora BrozziDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Cristina CosentinoDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Cécile JacovettiDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Claudiane GuayDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Jérôme PerrardDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Romano RegazziDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-9773-2915

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small non-coding RNAs, such as microRNAs and tRNA-derived fragments, are key regulators of cellular processes, but the functions of small intronic RNAs (sinRNAs), a recently identified RNA class, remain largely unknown. Here, we report that two sinRNAs, sinR-D and sinR-T, are upregulated in pancreatic β-cells of NOD mice, a well-established model of type 1 diabetes. Using in vivo RNA-tagging, we demonstrate that these sinRNAs are packaged into extracellular vesicles released by infiltrating CD4

Indexed as

CD4-Positive T-LymphocytesCell CommunicationDiabetes Mellitus, Type 1Insulin-Secreting CellsIntronsRNA, Small UntranslatedAnimalsApoptosisArgonaute ProteinsMiceMice, Inbred NODAgo2 protein, mouseArgonaute ProteinsRNA, Small UntranslatedapoptosisDiabetesextracellular vesiclesisletnon-coding RNA

Identifiers

PMID41823267
PMCPMC12998025

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.