ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026
High-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The NeuroEXPLORER (NX), a next generation brain-dedicated PET scanner, has demonstrated improved spatial resolution and sensitivity compared with previous PET scanners. In this study, we performed synaptic vesicle glycoprotein 2A (SV2A) PET, an in vivo marker of synaptic density, to evaluate the performance of the NX in both fetal and maternal brains of four pregnant rhesus macaques. Results were compared with the previously acquired PET images using miniEXPLORER and Biograph mCT for fetal and maternal brains (four pregnant monkeys per scanner). The NX demonstrated superior performance compared with the other scanners, providing improved image clarity and higher distribution volume ratios (DVRs), which were significant in the occipital region and putamen of the fetal brain (
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