ArticleThe journal of extra-corporeal technology2026
Impact of early hyperoxia on outcomes during neonatal and pediatric veno-arterial extracorporeal life support★.
Article in The journal of extra-corporeal technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
Funding
Abstract
backgroundHyperoxia induces oxidative stress and can exacerbate inflammatory response to Veno-Arterial Extracorporeal Life Support (VA-ECLS). This study aimed to evaluate the association between hyperoxia during VA-ECLS and morbidity, complications, and in-hospital mortality.
methodsThis study included pediatric patients who received VA-ECLS between 2014 and 2019. Hyperoxia severity was categorized as mild (PaO
resultsAmong 229 patients supported on VA-ECLS runs, 73.4% involved neonates. Median age and weight of the entire cohort were 2.5 months (IQR 0.3, 19.0), and 4.4 kg (IQR 3.2, 10.7), respectively. Cardiac indications accounted for 48.9% of cases. Hyperoxia occurred in 79% of patients and was more common in those requiring ECLS for cardiac indications. The overall in-hospital mortality rate was 45%, increasing to 64% in the severe hyperoxia cohort (p = 0.23). Severe hyperoxia was significantly associated with the composite outcome of cardiovascular or renal complications but not in-hospital mortality in multivariable analysis. No association was found between hyperoxia, AKI, and adverse functional outcomes.
conclusionsStandardized PaO
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