Evidence map›Paper›PMID 41823606›Full record

Trial reportRadiology. Imaging cancer2026

Quantifying Functional Liver Volume Loss after CT-guided Percutaneous Thermal Ablation: A COVER-ALL Trial Post Hoc Analysis.

Noreen S Siddiqi, Jessica Albuquerque, Iwan Paolucci, Yuan-Mao Lin, Caleb O'Connor, Antony Haddad, Aaron K Jones, Jean-Nicholas Vauthey, Kristy K Brock, Bruno C Odisio

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Radiology. Imaging cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noreen S Siddiqi *Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030.ORCID 0009-0002-9738-6431
Jessica Albuquerque *Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030.ORCID 0000-0003-0616-982X
Iwan PaolucciDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030.ORCID 0000-0002-9393-3015
Yuan-Mao LinDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030.ORCID 0000-0002-0275-9593
Caleb O'ConnorDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex.
Antony HaddadDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Tex.
Aaron K JonesDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex.ORCID 0000-0001-8245-8573
Jean-Nicholas VautheyDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Tex.
Kristy K BrockDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Tex.ORCID 0000-0001-9364-5040
Bruno C OdisioDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1471, Houston, TX 77030.ORCID 0000-0002-1771-8233

Funding

Image Guided Cancer Therapy Training ProgramT32CA261856 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kristy Brock, Clifton David Fuller · 2022 to 2026
$1.2M
NCI NIH HHS T32 CA261856
6 · The paper itself

Abstract

Purpose To quantify functional liver volume (FLV) loss relative to minimal ablative margins (MAMs) achieved during percutaneous thermal ablation (TA) of liver tumors in COVER-ALL randomized controlled trial (RCT) participants. Materials and Methods In the COVER-ALL single-center RCT (June 2020 through October 2023), software-based ablation confirmation (AC) (experimental) and visual margin (control) assessment were compared among participants with histology-agnostic liver tumors. In this post hoc analysis, the authors compared CT-derived volumes, MAMs, and changes in laboratory-based hepatic function using Wilcoxon rank sum and Spearman correlation tests. Results Among 100 participants (mean age ± SD, 57.8 years ± 13.2; 61 male; experimental group,

Indexed as

Catheter AblationLiverLiver NeoplasmsSurgery, Computer-AssistedTomography, X-Ray ComputedAdultAgedFemaleHumansMaleMargins of ExcisionMiddle AgedOrgan SizeAblation TechniquesLiverSegmentationVolume Analysis

Identifiers

PMID41823606
PMCPMC13036685

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.