Behavioral Alterations in Male Zebrafish After Administration of Androgen Receptor Blockers and an Activator.

Ching-Yu Huang, Gilbert Audira, Ross D Vasquez, Honeymae C Alos, Hung-Yu Lin, Chung-Der Hsiao, Chih-Hsin Hung

Abstract read

In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ching-Yu HuangInstitute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung 840203, Taiwan.

Gilbert AudiraDepartment of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.

Ross D VasquezDepartment of Pharmacy, Faculty of Pharmacy, University of Santo Tomas, Manila 1015, Philippines.ORCID 0000-0002-5906-9710

Honeymae C AlosResearch Center for the Natural and Applied Sciences, University of Santo Tomas, Manila 1015, Philippines.

Hung-Yu LinSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung 84001, Taiwan.

Chung-Der HsiaoDivision of Urology, Department of Surgery, E-Da Dachang Hospital, Kaohsiung 80794, Taiwan.ORCID 0000-0002-6398-8672

Chih-Hsin HungInstitute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung 840203, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Androgen receptor (AR) signaling is crucial for mediating male-typical behaviors across vertebrates. Enzalutamide (ENZ) and apalutamide (APA) are two second-generation androgen receptor inhibitors (SGARIs) that have been primarily used in the treatment of prostate cancer. However, these drugs still possess side effects, and there remains limited information regarding their behavioral and neurophysiological impacts following chronic exposure in non-mammalian animal models, particularly in fish. Thus, this study aimed to evaluate the behavioral alterations in adult male zebrafish (

Indexed as

androgenapalutamidebehaviordihydrotestosteroneenzalutamidezebrafish

Identifiers

PMID41823821

DOI10.3390/biology15050393

PMCPMC12984835

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.