Deep Learning-Enabled Multi-Omics Integration: A New Frontier in Precise Drug Target Discovery.

Precise drug target discovery is pivotal to mitigating the escalating costs and high attrition rates that characterize pharmaceutical research and development. Given that traditional single-omics methods often fail to elucidate the systemic complexity of human diseases, deep learning (DL)-enabled multi-omics integration has emerged as a transformative frontier. This review systematically summarizes the advancements in DL-driven multi-omics integration for drug target discovery. First, the multi-omics data foundation and integration strategies are delineated, followed by an exploration of the DL architectures utilized for processing such data. Subsequently, the efficacy of DL-driven multi-omics integration is examined regarding the identification of novel disease drivers, prediction of synthetic lethality interactions, and prioritization of therapeutic targets. Finally, addressing persistent challenges related to data sparsity, model interpretability, and target druggability and validation hurdles, emerging opportunities driven by Generative AI, Large Multimodal Models (LMMs), Explainable AI (XAI), and multidimensional feasibility assessment frameworks are discussed in the context of advancing precision medicine.