Evidence mapPaperPMID 41824006Full record

ReviewVeterinary research communications2026

Decoding sebaceous gland functions and diseases: insights from domestic animals.

Helga Pfannkuche, Juliane Maus, Kathrin M Engel, Jürgen Schiller, Marlon R Schneider

Abstract readReview
In one paragraph

Review in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Helga PfannkucheInstitute of Veterinary Physiology, Leipzig University, An den Tierkliniken 7, 04103, Leipzig, Germany.
Juliane MausInstitute of Veterinary Physiology, Leipzig University, An den Tierkliniken 7, 04103, Leipzig, Germany.
Kathrin M EngelInstitute of Medical Physics and Biophysics, Faculty of Medicine, Leipzig University, Härtelstr. 16-18, 04107, Leipzig, Germany.
Jürgen SchillerInstitute of Medical Physics and Biophysics, Faculty of Medicine, Leipzig University, Härtelstr. 16-18, 04107, Leipzig, Germany.
Marlon R SchneiderInstitute of Veterinary Physiology, Leipzig University, An den Tierkliniken 7, 04103, Leipzig, Germany. marlon.schneider@vetmed.uni-leipzig.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin sebaceous glands (SGs) synthesize and secrete sebum, a mixture of lipids and cellular debris that defends the external body surface against physicochemical challenges. Recent data define the SG as a dynamic entity with potential functions beyond skin protection, including immunomodulatory actions and the regulation of energy metabolism. We postulate that the SG also has important, unrecognized roles in physiological and pathological processes in domestic animals. Conversely, data derived from domestic animals may have translational relevance for humans. This review article summarizes SG structural and functional features in the most widespread species domesticated for food (cattle, sheep, goats, and pigs), work (horses), and companionship (dogs and cats). Our survey reveals hitherto unrecognized roles of the SG in diverse pathophysiological processes. Among other fascinating facts, we learn that sebum has an exquisite and unique lipid composition in each of the considered species. Furthermore, sebum is essential for e.g., wool production but also a carrier for the most important cat protein causing allergic reactions in humans, and dogs and cats may develop a SG-related skin illness resembling acne that is potentially relevant as a model for the human disease. This critical review provides a foundation for future interdisciplinary studies in a largely neglected area with great potential for advancing animal welfare and human health.

Indexed as

Animals, DomesticSebaceous GlandsAnimalsCatsHumansSebumDomestic animalsMeibomian glandsSebaceous glandsSebumSkin physiology

Identifiers

PMID41824006
PMCPMC12987846

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.