Evidence map›Paper›PMID 41824523›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long-Term Active Place Avoidance Memory and "Shadow" Proteins.

Jiyeon Han, Alejandro Grau-Perales, Rayna M Harris, Edith Lesburguères, Hsin-Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C Sacktor, Stefano Martiniani, Hans A Hofmann and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. PKMζ-KIBRA interactions, molecular turnover, and memory.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jiyeon HanCenter for Neural Science, New York University, New York, New York, USA.ORCID https://orcid.org/0000-0002-6001-1540
Alejandro Grau-PeralesCenter for Neural Science, New York University, New York, New York, USA.
Rayna M HarrisDepartment of Integrative Biology and Institute for Neuroscience, The University of Texas. Austin, Austin, Texas, USA.
Edith LesburguèresCenter for Neural Science, New York University, New York, New York, USA.
Hsin-Yi KaoCenter for Neural Science, New York University, New York, New York, USA.
Asit PalCenter for Soft Matter Physics, Department of Physics, New York University, New York, New York, USA.
Juan Marcos AlarconDepartment of Pathology. State University of New York, Downstate Health Sciences University, Brooklyn, New York, USA.
Todd C SacktorDepartments of Physiology and Pharmacology, Anesthesiology, and Neurology, State University of New York, Downstate Health Sciences University, Brooklyn, New York, USA.
Stefano MartinianiCenter for Neural Science, New York University, New York, New York, USA.
Hans A HofmannDepartment of Integrative Biology and Institute for Neuroscience, The University of Texas. Austin, Austin, Texas, USA.ORCID https://orcid.org/0000-0002-3335-330X
André A FentonCenter for Neural Science, New York University, New York, New York, USA.ORCID https://orcid.org/0000-0002-5063-1156

Funding

Molecular mechanisms of memory maintenance and dysfunction in neural circuitsR01MH115304 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI FENTON, ANDRE ANTONIO, SACKTOR, TODD C · 2018 to 2022
$4.1M
Towards a critical test of the synaptic plasticity and memory hypothesisR01MH132204 · NIMH · NEW YORK UNIVERSITY · PI ANDRE ANTONIO FENTON · 2023 to 2026
$2.5M
Chan Zuckerberg Initiative CP2-1-0000000614NIH HHS R01MH115304NIH HHS R01MH132204NIMH NIH HHS R01 MH115304NIMH NIH HHS R01 MH132204Simons Foundation 839534UT Austin Continuing Fellowship to RMH
6 · The paper itself

Abstract

Long-term memory formation transiently activates Ca

Indexed as

Avoidance LearningHippocampusMemory, Long-TermProtein Kinase CAnimalsGene Expression ProfilingProtein Kinase C zetaRatsTranscriptomeProtein Kinase CProtein Kinase C zetaprotein kinase M zeta, ratengramgene co‐expression networksimmunohistochemistrytranscriptometrisynaptic pathway

Identifiers

PMID41824523
PMCPMC13185853

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.