Evidence map›Paper›PMID 41824581›Full record

ArticleScience advances2026

0.33

Ryosuke Tsuji, Ryo Fujita, Takuto Hayashi, Shunya Sadaki, Tatsuya Matsumoto, Yuri Inoue, Yuka Murakami, Michito Hamada, Masafumi Muratani, Hiroe Kobayashi and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Ryosuke TsujiLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.ORCID 0009-0001-0430-6731
Ryo FujitaDivision of Regenerative Medicine, Transborder Medical Research Center, Institute of Medicine, University of Tsukuba Ibaraki, Ibaraki 305-8575, Japan.ORCID 0000-0002-8392-0122
Takuto HayashiLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.ORCID 0009-0007-6313-4347
Shunya SadakiLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Tatsuya MatsumotoLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Yuri InoueLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Yuka MurakamiLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Michito HamadaLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.ORCID 0000-0002-4737-1007
Masafumi MurataniDepartment of Genome Biology, Transborder Medical Research Center, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.ORCID 0000-0002-0276-8000
Hiroe KobayashiSpace Environment Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Ibaraki 305-8505, Japan.ORCID 0009-0005-9684-8050
Akane YumotoSpace Environment Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Ibaraki 305-8505, Japan.
Maki OkadaSpace Environment Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Ibaraki 305-8505, Japan.
Daisuke KamimuraSpace Environment Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Ibaraki 305-8505, Japan.
Risa OkadaSpace Environment Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Ibaraki 305-8505, Japan.ORCID 0009-0006-3962-4090
Takafumi SuzukiTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.ORCID 0000-0002-3425-8208
Ryo KurosawaTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.ORCID 0000-0002-9957-5327
Akihito OtsukiTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.ORCID 0000-0003-1516-1010
Seizo KoshibaTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.ORCID 0000-0003-2001-1949
Martha Hotz VitaternaDepartment of Neurobiology, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-6243-2093
Charles A FullerDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, CA, USA.ORCID 0000-0002-9831-7473
Marie MortreuxUniversity of Rhode Island, Kingston, RI, USA.ORCID 0000-0001-8567-8184
Dong-Min SungBeth Israel Deaconess Medical Center, Department of Neurology, Harvard Medical School, Boston, MA, USA.
Jason CiolaBrigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-9352-6321
Seward B RutkoveBeth Israel Deaconess Medical Center, Department of Neurology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6375-3312
Jennifer CoulombeCenter for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA.
Takashi KudoLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.ORCID 0000-0001-5477-7235
Masayuki YamamotoTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.ORCID 0000-0002-9073-9436
Mary L BouxseinCenter for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7027-7414
Dai ShibaSpace Environment Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Ibaraki 305-8505, Japan.ORCID 0000-0003-3808-5428
Satoru TakahashiLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.ORCID 0000-0002-8540-7760

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As human space exploration advances, understanding how different gravity levels affect skeletal muscle is critical for long-term health. Among the major organ systems, skeletal muscle is particularly sensitive to gravitational unloading, yet the gravity threshold required to maintain homeostasis remains unclear. Using the Multiple Artificial-gravity Research System aboard the International Space Station, mice were exposed to graded gravity levels, microgravity, 0.33

Indexed as

Muscle Fibers, SkeletalMuscle, SkeletalMuscular AtrophySpace FlightAnimalsMaleMetabolomicsMiceWeightlessness

Identifiers

PMID41824581
PMCPMC12985678

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.