Evidence map›Paper›PMID 41824793›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Context-Dependent Role of GDF15: GDF15

Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinyu ZhouDepartment of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Zhihang ZhouDepartment of Stomatology, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Houyu JuDepartment of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Chaoyang GuoDepartment of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Fangxing ZhuDepartment of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Yiyi ZhangShanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology & National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, P. R. China.
Xu ChenDepartment of Laboratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Tongchao ZhaoDepartment of Stomatology, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Laiping ZhongDepartment of Stomatology, Huashan Hospital, Fudan University, Shanghai, P. R. China.
Jingzhou HuDepartment of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.ORCID https://orcid.org/0000-0003-4402-3370

Funding

Clinical Scientist Development Program of Fudan University DGF828024-2/032Excellent Academic Leader Program of Shanghai Oriental Talent Plan BJWS2024045National Natural Science Foundation of China 82172734National Natural Science Foundation of China 82372623National Natural Science Foundation of China 82473268Shanghai Sailing Program 22YF1421700Shanghai Sailing Program 24YF2722800
6 · The paper itself

Abstract

The growth differentiation factor 15 (GDF15) neutralizing antibody has shown to overcome resistance to immune checkpoint blockade (ICB) in various solid tumors. Though the therapeutic effect of GDF15 neutralizing antibody indicates a protumor role of secreted GDF15, the double-edged effect of GDF15 has remained a mystery for a long. Herein, we performed single-cell RNA-sequencing on oral squamous cell carcinoma (OSCC) samples before and after ICB-based therapy to explore the context-dependent functions of GDF15 across distinct cellular subsets. It revealed that GDF15

Indexed as

Growth Differentiation Factor 15Mouth NeoplasmsPhagocytosisTumor-Associated MacrophagesAnimalsCD8-Positive T-LymphocytesDisease ProgressionHumansMiceGDF15 protein, humanGdf15 protein, mouseGrowth Differentiation Factor 15growth differentiation factor 15immune checkpoint blockadeoral squamous cell carcinomaphagocytosis

Identifiers

PMID41824793
PMCPMC13205754

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.