ArticleMedicine2026
Non-HDL to HDL cholesterol ratio as a potential biomarker for osteoporosis: A cross-sectional national population study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This cross-sectional study aimed to investigate the association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and osteoporosis (OP) among US women. An analysis was conducted using data from 6149 women participating in the National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression and restricted cubic spline models were applied to evaluate the relationship between NHHR and OP, with adjustments for sociodemographic, clinical, and metabolic covariates. After full adjustment, a significant U-shaped relationship was identified between NHHR and osteoporosis prevalence, with an inflection point at NHHR = 3.371. Below this threshold, each unit increase in NHHR was associated with a 29% reduction in OP risk (odds ratio = 0.71, 95% confidence intervals: 0.60-0.84, P < .001). No significant association was observed above this value. Inverse associations were particularly notable in women aged ≥65 years, non-Hispanic Whites, former smokers, and those with higher education or lower physical activity levels. Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio demonstrates a nonlinear, threshold-dependent association with osteoporosis risk, supporting its potential role as a novel biomarker for OP in specific subpopulations. Further prospective studies are warranted to clarify causal mechanisms.
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Registered trials
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