Trial reportJournal of the National Comprehensive Cancer Network : JNCCN2026
Effects of Exercise on Cognitive Impairment in Patients Receiving Chemotherapy: A Multicenter Phase III Randomized Controlled Trial.
Trial report in Journal of the National Comprehensive Cancer Network : JNCCN, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Trial
- Methodology of analysis of cognitive impairment in longitudinal randomized clinical trials in oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
Abstract
backgroundUp to 75% of patients experience cancer-related cognitive impairment (CRCI) during treatment. CRCI often co-occurs with mental fatigue. Chemotherapy may cause cognitive impairment and mental fatigue by compromising systemic inflammatory responses, whereas exercise may induce a self-regulating inflammatory response and promote immunocompetence. Exercise-induced immunocompetence may lead to improvements in CRCI and mental fatigue. We examined the effects of exercise on CRCI and mental fatigue, as well as the relationships between exercise and CRCI and between inflammatory responses and CRCI, in patients receiving chemotherapy in a multicenter phase III randomized controlled trial. PATIENTS AND
methodsPatients diagnosed with any cancer type and scheduled to start chemotherapy were randomized to either a 6-week home-based, individually tailored exercise intervention-Exercise for Cancer Patients (EXCAP)-or usual care. The Functional Assessment of Cancer Therapy-Cognitive Function and the Multidimensional Fatigue Symptom Inventory were used to assess cognitive impairment and mental fatigue, respectively. Blood samples were collected to assess inflammation (ie, IL-1β, IL-6, IL-8, IL-10, IFN-γ, and sTNFR1). Analysis of covariance (ANCOVA) was used to examine between-group differences in CRCI and mental fatigue. Structural equation modeling was conducted to examine the relationships between exercise and CRCI and between inflammatory responses and CRCI.
resultsCompared with participants receiving usual care, EXCAP participants undergoing chemotherapy on 2-week cycles reported less overall cognitive impairment (mean difference [SE], 7.0 [3.3]; P=.04), perceived cognitive impairment (4.1 [2.1]; P=.05), comments from others identifying cognitive impairment (0.6 [0.2]; P=.02), and mental fatigue (-1.6 [0.5]; P<.01). All EXCAP participants, regardless of chemotherapy cycle duration, reported less mental fatigue compared with participants receiving usual care (-0.7 [0.3]; P=.02). Suppressed inflammatory responses were associated with CRCI in participants receiving chemotherapy (0.2 [0.1]; P<.01).
conclusionsEXCAP may reduce CRCI and mental fatigue, particularly in patients receiving 2-week cycles of chemotherapy. A healthy inflammatory response, characterized by increases in both proinflammatory and anti-inflammatory cytokines, is associated with less cognitive impairment during chemotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.