Evidence map›Paper›PMID 41825960›Full record

ArticleLife science alliance2026

Mutual feedback regulation between Poly(A)-specific ribonuclease (PARN) and cognate microRNAs.

Athanasios Kyritsis, Rafailia Aa Beta, Diana Scutelnic, Vasiliki Stravokefalou, Valerio Del Vescovo, Zoi V Arsenopoulou, Konstantinos Papikinos, Margherita Grasso, Francesca Fontana, Paraskevi Moutopoulou and 5 more

Abstract read
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In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Athanasios KyritsisDepartment of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
Rafailia Aa BetaDepartment of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
Diana ScutelnicDepartment of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
Vasiliki StravokefalouDepartment of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
Valerio Del VescovoDepartment of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento, Italy.
Zoi V ArsenopoulouDepartment of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
Konstantinos PapikinosDepartment of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.ORCID 0009-0007-2018-6577
Margherita GrassoDepartment of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento, Italy.
Francesca FontanaDepartment of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento, Italy.
Paraskevi MoutopoulouDepartment of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
Alexandros TsiporisDepartment of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
Martina SamiotakiB.S.R.C. "Alexander Fleming", Vari, Greece.
George PanayotouB.S.R.C. "Alexander Fleming", Vari, Greece.
Michela A DentiDepartment of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento, Italy michela.denti@unitn.it.ORCID 0000-0001-7203-7062
Nikolaos Aa BalatsosDepartment of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece balatsos@bio.uth.gr.ORCID 0000-0002-1146-1174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The majority of pri-miRNAs acquire a 5' cap and 3' poly(A) tail. Mature miRNAs recruit deadenylases that shorten poly(Α) tails triggering target mRNA degradation. Poly(A)-specific ribonuclease (PARN) is a deadenylase that also mediates late steps of noncoding RNA maturation. Herein, we show that PARN affects the expression of a subset of miRNAs in NCI-H520 cells of lung cancer origin, including miR-29a and miR-1207, which are also predicted to target PARN mRNA. PARN associates with pri-miR-29a and pri-miR-1207 regulating their poly(A) lengths. Conversely, miR-29a-3p and miR-1207-5p bind the 3' UTR of PARN mRNA and regulate its expression. Cleavage and polyadenylation specificity factor 6 (CPSF6) recruits PARN to pri-miRNAs and together they affect primary and mature miR-29a-3p levels. Modulation of PARN, miR-29a-3p, or miR-1207-5p expression affects cell migration. We present a model to describe the dynamic relation between PARN and miR-29a and discuss its biological significance.

Indexed as

ExoribonucleasesMicroRNAs3' Untranslated RegionsCell Line, TumorCleavage And Polyadenylation Specificity FactorFeedback, PhysiologicalGene Expression Regulation, NeoplasticHumansLung NeoplasmsPoly ARibonucleasesRNA, MessengerRNA Stability3' Untranslated RegionsCleavage And Polyadenylation Specificity FactorExoribonucleasesMicroRNAsMIRN29a microRNA, humanmRNA deadenylasePoly ARibonucleasesRNA, Messenger

Identifiers

PMID41825960
PMCPMC12988311

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.