Evidence map›Paper›PMID 41826372›Full record

ArticleNPJ systems biology and applications2026

Neuronal and glial networks interact with traumatic brain injury to modulate cognition in ABCD study.

Michael Cheng, Melody Mao, Wenjing Meng, Joanna Jacobus, Emily A Troyer, Everett L Delfel, Emily L Dennis, Elisabeth A Wilde, Tracy Abildskov, Nicola L de Souza and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ systems biology and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michael ChengDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Melody MaoDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Wenjing MengDivision of Biostatistics, School of Public Health, University of California, San Diego, San Diego, CA, USA.
Joanna JacobusDepartment of Psychiatry, University of California, San Diego, San Diego, CA, USA.
Emily A TroyerDepartment of Psychiatry, University of California, San Diego, San Diego, CA, USA.
Everett L DelfelJoint Doctoral Program in Clinical Psychology, San Diego State University / University of California, San Diego, San Diego, CA, USA.
Emily L DennisDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Elisabeth A WildeDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Tracy AbildskovDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Nicola L de SouzaDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Florin VaidaDivision of Biostatistics, School of Public Health, University of California, San Diego, San Diego, CA, USA. fvaida@health.ucsd.edu.
Jeffrey E MaxDepartment of Psychiatry, University of California, San Diego, San Diego, CA, USA. jmax@health.ucsd.edu.
Xia YangDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, USA. xyang123@ucla.edu.

Funding

Precision Medicine Approach: Using genomic information to guide TBI treatmentR01NS111378 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMEZ-PINILLA, FERNANDO, YANG, XIA · 2020 to 2024
$2.9M
Spatiotemporal Molecular Substrates of TBI at Single Cell ResolutionR01NS117148 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMEZ-PINILLA, FERNANDO, WOLLMAN, ROY · 2020 to 2024
$2.8M
Pediatric Mild Traumatic Brain Injury and the ABCD Study: A Prospective Behavioral, Psychiatric, Neurocognitive, Imaging, and Genetic InvestigationR01HD105338 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEFFREY Edwin MAX · 2022 to 2026
$2.3M
National Institute of Child Health and Human Development HD111167NICHD NIH HHS R01 HD105338NIDA NIH HHS DA041089NINDS NIH HHS NS111378NINDS NIH HHS R01 NS111378NINDS NIH HHS R01 NS117148
6 · The paper itself

Abstract

Mild traumatic brain injury (mTBI) disproportionately affects children and adolescents and has been associated with poorer neurocognitive performance, but the biological mechanisms driving symptom variability and severity remain understudied. In accordance with the omnigenic disease model, we integrated gene-by-mTBI interaction genome-wide association studies on neurocognition from the Adolescent Brain Cognitive Development (ABCD) cohort with single-cell RNA sequencing gene regulatory networks to elucidate the cell type-specific key regulators and molecular mechanisms governing neurocognitive outcome of mTBI, specifically learning and memory performance. Our analysis revealed distinct network regulators in neuronal and glial cell types across hippocampal and cortical brain regions to orchestrate key neurodevelopmental pathways. Examples include APP for synaptic signaling in excitatory neurons, COX5A for mitochondrial function in inhibitory neurons, MOG for myelination in oligodendrocytes in the hippocampus; GRM7 for synaptic signaling in excitatory neurons, SV2A for synaptic signaling in inhibitory neurons, and MOG for myelination in oligodendrocytes in the cortex. These mechanisms also associate with learning and memory through pathway-based polygenic risk score modeling in ABCD. Our findings provide brain region- and cell type-specific insights into the complex regulatory network landscape of mTBI pathology and potential therapeutic candidates at the pathway and network levels.

Indexed as

Brain Injuries, TraumaticCognitionNeurogliaNeuronsBrainGene Regulatory NetworksGenome-Wide Association StudyHumansMaleNeurodevelopment

Identifiers

PMID41826372
PMCPMC13128933

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.