Evidence map›Paper›PMID 41826410›Full record

ArticleScientific reports2026

ITPR3 promotes liver fibrosis by damaging hepatocytes via the Ca2+/NF-B/LECT2 pathway.

Xiaojuan Zhao, Xue Liu, Min Ni, Linlin Cao, Yaxuan Zhao, Jiankang Zhang, Hua Zhang, Jing Ye

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaojuan ZhaoSchool of Pharmacy, Yancheng Teachers University, No.2, Xiwang South Road, Tinghu District (224007), Yancheng, 224007, Jiangsu, P. R. China. zhaoxj@yctu.edu.cn.
Xue LiuSchool of Pharmacy, Yancheng Teachers University, No.2, Xiwang South Road, Tinghu District (224007), Yancheng, 224007, Jiangsu, P. R. China.
Min NiSchool of Pharmacy, Yancheng Teachers University, No.2, Xiwang South Road, Tinghu District (224007), Yancheng, 224007, Jiangsu, P. R. China.
Linlin CaoSchool of Pharmacy, Yancheng Teachers University, No.2, Xiwang South Road, Tinghu District (224007), Yancheng, 224007, Jiangsu, P. R. China.
Yaxuan ZhaoSchool of Pharmacy, Yancheng Teachers University, No.2, Xiwang South Road, Tinghu District (224007), Yancheng, 224007, Jiangsu, P. R. China.
Jiankang ZhangSchool of Pharmacy, Yancheng Teachers University, No.2, Xiwang South Road, Tinghu District (224007), Yancheng, 224007, Jiangsu, P. R. China.
Hua ZhangSchool of Pharmacy, Yancheng Teachers University, No.2, Xiwang South Road, Tinghu District (224007), Yancheng, 224007, Jiangsu, P. R. China. zhangh01@yctu.edu.cn.
Jing YeSchool of Pharmacy, Yancheng Teachers University, No.2, Xiwang South Road, Tinghu District (224007), Yancheng, 224007, Jiangsu, P. R. China. yej@yctu.edu.cn.

Funding

Institute Nature Science Fund of Jiangsu Province 19KJB310026Institute Nature Science Fund of Jiangsu Province 20KJB310026Jiangsu Provincial Science and Technology Plan Special Fund (Basic Research Plan Natural Science Foundation) General Project BK20231358National Natural Science Foundation of China 32272995National Natural Science Foundation of China 82505111Outstanding Science and Technology Innovation Team Project of Jiangsu Provincial University, Biopharmaceuticals and Nano Diagnostic and Therapeutic Materials 2023-35Qing Lan Project of Jiangsu Provincial University 2023Yancheng City Science and Technology Project YCBE202333
6 · The paper itself

Abstract

Hepatocyte damage is the initial factor in liver injury. De novo expression of inositol 1,4,5-triphosphate receptor type 3 (ITPR3) typically occurs in hepatocellular carcinoma and may contribute to its pathogenesis. However, the role of de novo expression of ITPR3 by hepatocytes in the pathological processes of liver fibrosis remains unclear. Expression analyses of ITPR3 in hepatocytes were combined with an evaluation Ca

Indexed as

CalciumHepatocytesInositol 1,4,5-Trisphosphate ReceptorsIntercellular Signaling Peptides and ProteinsLiver CirrhosisNF-kappa BAnimalsApoptosisCarbon TetrachlorideMaleMiceMice, Inbred C57BLSignal TransductionCalciumCarbon TetrachlorideInositol 1,4,5-Trisphosphate ReceptorsIntercellular Signaling Peptides and ProteinsLect2 protein, mouseNF-kappa BHepatocytes apoptosisITPR3LECT2Liver fibrosisNF-κB

Identifiers

PMID41826410
PMCPMC13106706

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.