Trial reportScientific reports2026
Peri-implant soft tissue health and denture base adaptation of CAD/CAM milled versus 3D-printed implant-assisted mandibular overdentures: one-year randomized clinical trial.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06166446 (Comparison of Denture Base Adaptation and Per-implant Tissue Health Between CAD and CAM Implant Retained Complete Overdenture), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Denture Base Adaptation and Per-implant Tissue Health Between CAD and CAM Implant Retained Complete Overdenture
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to compare denture base adaptation and peri-implant soft tissue health between CAD/CAM milled and 3D-printed mandibular implant-assisted overdentures. Twenty-four completely edentulous patients were enrolled and randomly allocated to two groups. After two dropouts, twenty-two patients completed the trial (11 per group). All patients received two implants in the mandibular canine region with ball attachments. The intervention group received a CAD/CAM milled mandibular overdenture, while the control group received a 3D-printed mandibular overdenture; both groups received a conventional maxillary complete denture. Peri-implant soft tissue health was assessed using clinical parameters, including Gingival Index (GI), Plaque Index (PI), Bleeding Index (BI), and Probing depth (PD) at insertion (T0), six months (T6), and one year (T12) after denture insertion. The adaptation of the denture base for both groups was assessed by digital surface matching software (Geomagic). Regarding peri-implant soft tissue health, clinical parameters increased significantly with time for both groups, and there was no significant difference in all parameters between the two groups at all observational times. The whole surface adaptation between the two groups was significantly different, with Group I showing significantly higher adaptation than Group II. Within the limitations of this study, CAD/CAM milled implant-assisted mandibular overdentures demonstrated superior denture base adaptation compared to their 3D-printed counterparts. This finding underscores the precision achievable with subtractive manufacturing for definitive prostheses. Regarding the peri-implant tissues, both groups maintained comparable and stable levels of plaque control and gingival health throughout the observation period.Clinical Trial Registration Number: No. NCT06166446.
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