Evidence map›Paper›PMID 41827249›Full record

ReviewJournal of clinical medicine2026

Protective Ventilation During Controlled and Partial Ventilatory Support in ARDS: Clinical-Physiological Background and Monitoring.

Rodrigo A Cornejo, Caio C A Morais, Daniel H Arellano, Roberto Brito, Abraham I J Gajardo, Marioli T Lazo, Leonore B D Bos, Roberto González, Alejandro R Bruhn, Jan Bakker

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rodrigo A CornejoUnidad de Pacientes Críticos, Departamento de Medicina, Hospital Clínico Universidad de Chile, Santiago 8380456, Chile.ORCID 0000-0002-0497-5740
Caio C A MoraisUnidade de Terapia Intensiva Adulto, Hospital das Clínicas Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
Daniel H ArellanoUnidad de Pacientes Críticos, Departamento de Medicina, Hospital Clínico Universidad de Chile, Santiago 8380456, Chile.
Roberto BritoUnidad de Pacientes Críticos, Departamento de Medicina, Hospital Clínico Universidad de Chile, Santiago 8380456, Chile.
Abraham I J GajardoPrograma de Fisiopatología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
Marioli T LazoDepartamento de Kinesiología, Facultad de Medicina, Universidad Andrés Bello, Santiago 7591538, Chile.
Leonore B D BosErasmus MC University Medical Center, Faculty of Medicine, Erasmus University Rotterdam, 3015 GD Rotterdam, The Netherlands.
Roberto GonzálezDepartamento de Anestesia y Medicina Perioperatoria, Hospital Clínico Universidad de Chile, Santiago 8380456, Chile.ORCID 0000-0001-6253-0267
Alejandro R BruhnDepartamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
Jan BakkerDepartment of Intensive Care Adults, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-2236-7391

Funding

Fondo Nacional de Desarrollo Científico y Tecnológico 1221829
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is characterized by severe hypoxemia, low lung compliance, and marked regional heterogeneity of aeration, making the lung highly vulnerable to injurious mechanical forces. Mechanical ventilation is essential to maintain gas exchange. However, excessive stress and strain may contribute to ventilator-induced lung injury (VILI). The progressive transition to partial ventilatory support introduces an additional risk: patient self-inflicted lung injury (P-SILI), driven by vigorous inspiratory efforts, large transpulmonary pressure swings, pendelluft, and heterogeneous regional strain. Advances in monitoring, imaging, and physiology-based management offer the potential to reduce lung injury and improve outcomes in mechanically ventilated patients with ARDS. This review aims to summarize the clinical-physiological background of VILI and P-SILI, describe protective strategies during controlled and partially assisted ventilation, and discuss monitoring tools to personalize mechanical ventilation in ARDS.

Indexed as

acute respiratory distress syndromepatient self-inflicted lung injuryprotective ventilationventilator-induced lung injury

Identifiers

PMID41827249
PMCPMC12985527

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.