Evidence map›Paper›PMID 41827301›Full record

ReviewJournal of clinical medicine2026

Metabolic Dysfunction in Alzheimer's Disease: Brain Glucose Hypometabolism as an Early Precursor to Amyloid and Tau Pathology.

Rafail C Christodoulou, Daniel Eller, Platon S Papageorgiou, Efthalia Angelopoulou, Evros Vassiliou, Sokratis G Papageorgiou

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rafail C ChristodoulouDivision of Neuroimaging and Neurointervention, Department of Radiology, Stanford University, Stanford, CA 94304, USA.ORCID 0009-0001-6857-3927
Daniel EllerDivision of Neuroimaging and Neurointervention, Department of Radiology, Stanford University, Stanford, CA 94304, USA.ORCID 0000-0002-8399-2759
Platon S PapageorgiouDepartment of Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0009-0007-6102-3344
Efthalia Angelopoulou1st Department of Neurology, Medical School, National and Kapodistrian University of Athens, Eginition Hospital, 15772 Athens, Greece.ORCID 0000-0002-1426-3384
Evros VassiliouDepartment of Biological Sciences, Kean University, Union, NJ 07083, USA.
Sokratis G Papageorgiou1st Department of Neurology, Medical School, National and Kapodistrian University of Athens, Eginition Hospital, 15772 Athens, Greece.ORCID 0000-0001-8863-3635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer’s diseaseApoε4glucose metabolismmetabolic failureproteinopathiestype 3 diabetes

Identifiers

PMID41827301
PMCPMC12986246

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.