ReviewCells2026
Oral Cellular Homeostasis and Occupational Wellbeing in Healthcare Professionals Under the Lens of Salivary, Immune, and Microbiome Mechanisms.
Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHealthcare professionals experience continuous biological and psychosocial stressors that may disturb oral and systemic homeostasis. Alterations in salivary secretion, mucosal immunity, and microbiome composition reflect adaptive cellular responses to chronic occupational stress. Understanding these mechanisms may provide a biological framework for resilience and wellbeing in everyday clinical practice.
objectiveTo narratively review the evidence linking oral cellular and molecular mechanisms-salivary biomarkers, epithelial and immune cell activity, and microbiome dynamics-with stress, fatigue, burnout, and wellbeing outcomes among healthcare professionals.
methodsThis narrative review employed a PRISMA-guided literature search of PubMed, Scopus, Web of Science, and Cochrane Oral Health to enhance transparency and coverage across databases. Given the heterogeneity of study designs and outcomes, data were synthesized thematically without quantitative pooling or formal meta-analysis. Methodological strength was evaluated qualitatively, focusing on biomarker validity, sampling conditions, and conceptual relevance. Eligible designs included observational, experimental, and interventional studies.
resultsEvidence from 99 studies suggests that chronic occupational stress elevates salivary cortisol, oxidative stress markers, and pro-inflammatory cytokines (IL-6, TNF-α), while reducing protective salivary immunoglobulin A and microbiome diversity. Balanced oral immune and microbial profiles were associated with better psychological adaptation and lower fatigue indices.
conclusionsOral cellular homeostasis offers a promising window into the biological underpinnings of occupational stress and resilience in healthcare professionals. Systematic integration of salivary and mucosal biomarkers into workplace wellbeing programs could enhance early detection of dysregulated stress physiology. Future interdisciplinary research should bridge oral biology, occupational medicine, and mental health to strengthen sustainable wellbeing strategies across the health workforce.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.