ArticleCells2026
Acute Depletion of Cited2 in Embryonic Stem Cells Disrupts Gene Networks Controlling Self-Renewal, Homeostasis, and Early Cell Fate Commitment.
Leonardo Mendes-Silva, Sara M Brigida, Marlene Trindade, João M A Santos, Lucas Rougier, Rui Machado, Ana Luísa Escapa, Agapios Sachinidis, Jessica L MacDonald, José Bragança
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Leonardo Mendes-SilvaFaculty of Medicine and Biomedical Sciences (FMCB), University of Algarve Campus Gambelas, 8005-139 Faro, Portugal.ORCID 0000-0002-5989-637X Sara M BrigidaDepartment of Biology, Program in Neuroscience, Syracuse University, 107 College Place, Syracuse, NY 13244, USA.ORCID 0000-0002-2118-5572 Marlene TrindadeFaculty of Medicine and Biomedical Sciences (FMCB), University of Algarve Campus Gambelas, 8005-139 Faro, Portugal.ORCID 0000-0001-7072-3392 João M A SantosFaculty of Medicine and Biomedical Sciences (FMCB), University of Algarve Campus Gambelas, 8005-139 Faro, Portugal.
Lucas RougierAlgarve Biomedical Center-Research Institute (ABC-RI), University of Algarve Campus Gambelas, 8005-139 Faro, Portugal.
Rui MachadoFaculty of Medicine and Biomedical Sciences (FMCB), University of Algarve Campus Gambelas, 8005-139 Faro, Portugal.ORCID 0000-0002-4080-2353 Ana Luísa EscapaFaculty of Medicine and Biomedical Sciences (FMCB), University of Algarve Campus Gambelas, 8005-139 Faro, Portugal.
Agapios SachinidisCenter for Physiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Robert-Koch-Str. 39, 50931 Cologne, Germany.
Jessica L MacDonaldDepartment of Biology, Program in Neuroscience, Syracuse University, 107 College Place, Syracuse, NY 13244, USA.ORCID 0000-0002-9111-5756 José BragançaFaculty of Medicine and Biomedical Sciences (FMCB), University of Algarve Campus Gambelas, 8005-139 Faro, Portugal.ORCID 0000-0001-9566-400X Funding
Algarve Biomedical Center (ABC) Bolsa de Investigação Translacional - José Mariano Gago by ABCNational Institute of Health NIH/NINDS R21HD115073
6 · The paper itselfAbstract
Cited2 is a transcriptional regulator essential for embryonic development and cellular homeostasis. Studies in vertebrate models highlight its critical roles in heart, placental, neural tube, and hematopoietic development. In humans, CITED2 variants are associated with congenital heart disease. Functionally, Cited2 interacts with the transcriptional co-regulators p300/CBP and modulates the activity of multiple transcription factors. In embryonic stem cells (ESC), Cited2 supports pluripotency, self-renewal, and differentiation potential. Here, we performed comparative transcriptomic analysis after acute Cited
Indexed as
Gene Expression RegulationGene Regulatory NetworksInduced Pluripotent Stem CellsMouse Embryonic Stem CellsRepressor ProteinsTrans-ActivatorsAnimalsCell Self RenewalFemaleGenomic InstabilityHomeostasisMaleMiceMice, Inbred C57BLMice, Mutant Strainsp300-CBP-Associated FactorCited2 protein, mousep300-CBP-Associated FactorRepressor ProteinsTrans-ActivatorsCited2embryonic stem cellsp300 and CBPpluripotency and cell fate regulation
Identifiers
PMID41827883
PMCPMC12984937
What Socratic holds
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LicenceCC BY
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