Evidence mapPaperPMID 41828322Full record

ArticleInternational journal of molecular sciences2026

Differential Effects of Apigenin on Normal and Squamous Oral Epithelial Cells Reveal Redox-Autophagy Signaling Vulnerabilities in OSCC.

Bianca Voicu Balasea, Miruna-Silvia Stan, Miruna Dinescu, Marina Imre, Radu Radulescu, Ana Cernega, Monica Musteanu, Alexandra Ripszky, Silviu Mirel Pituru

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bianca Voicu BalaseaThe Interdisciplinary Center for Dental Research and Development, "Carol Davila" University of Medicine and Pharmacy, 19-21 Jean Louis Calderon, 030167 Bucharest, Romania.ORCID 0009-0002-7073-3309
Miruna-Silvia StanDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.ORCID 0000-0002-6273-8540
Miruna DinescuDepartment of Prosthodontics, Faculty of Dentistry, "Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, Romania.ORCID 0009-0004-1872-9956
Marina ImreDepartment of Prosthodontics, Faculty of Dentistry, "Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, Romania.
Radu RadulescuDepartment of Biochemistry, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 17-23 Plevnei Street, 020021 Bucharest, Romania.
Ana CernegaDepartment of Organization, Professional Legislation and Management of the Dental Office, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 17-23 Plevnei Street, 020021 Bucharest, Romania.ORCID 0009-0003-6970-1307
Monica MusteanuDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Complutense of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-1753-3765
Alexandra RipszkyThe Interdisciplinary Center for Dental Research and Development, "Carol Davila" University of Medicine and Pharmacy, 19-21 Jean Louis Calderon, 030167 Bucharest, Romania.ORCID 0000-0002-4345-282X
Silviu Mirel PituruThe Interdisciplinary Center for Dental Research and Development, "Carol Davila" University of Medicine and Pharmacy, 19-21 Jean Louis Calderon, 030167 Bucharest, Romania.ORCID 0000-0001-6766-7772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to compare the responses of normal human gingival epithelial cells (HGEpiC) and oral squamous cell carcinoma cells (OECM-1) to apigenin, a natural flavonoid, focusing on redox balance, autophagy, and apoptosis. This study is among the first to directly compare apigenin-induced responses in normal and cancerous oral epithelial cells. Cells were exposed to apigenin for 24 or 48 h, with untreated cells as controls. Mitochondrial activity, ATP, ROS (H

Indexed as

ApigeninAutophagyCarcinoma, Squamous CellEpithelial CellsMouth NeoplasmsSignal TransductionAdenosine TriphosphateApoptosisCell Line, TumorCell ProliferationGingivaHumansMitochondriaOxidation-ReductionReactive Oxygen SpeciesAdenosine TriphosphateApigeninReactive Oxygen Speciesapigeninautophagygingival epithelial cellsoral squamous cell carcinomaROS

Identifiers

PMID41828322
PMCPMC12985067

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.