Evidence map›Paper›PMID 41828339›Full record

ArticleInternational journal of molecular sciences2026

Mona G El-Sisi, Sara M Radwan, Sameh S Ali, Mohamed Y Mostafa, Nadia M Hamdy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mona G El-SisiDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0002-1118-6731
Sara M RadwanDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0002-7994-093X
Sameh S AliResearch Department, Children's Cancer Hospital Egypt-57357, Cairo 11562, Egypt.
Mohamed Y MostafaDepartment of Clinical Oncology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Nadia M HamdyDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0003-2105-107X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early detection of hepatocellular carcinoma (HCC) remains challenging due to limitations including the lack of reliable biomarkers. While molecular diagnostics hold promise, their use is limited because tissue biopsies are not routinely performed in HCC. Long non-coding RNAs (lncRNA), such as HOXA transcript at the distal tip (HOTTIP), have been implicated in HCC, with single-nucleotide polymorphisms forming haplotypes that may influence disease progression. This study investigated the clinical relevance of HOTTIP SNPs rs17501292 and rs2067087 in 198 Egyptian HCC patients (129 non-metastatic, 69 metastatic). Moreover, molecular docking was used to design small interfering RNAs (siRNAs) targeting HOTTIP. Genotypes

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsPolymorphism, Single NucleotideRNA, Long NoncodingRNA, Small InterferingBiomarkers, TumorComputational BiologyFemaleGenotypeHumansMaleMiddle AgedMolecular Docking SimulationNeoplasm MetastasisPrognosisBiomarkers, Tumorlong noncoding RNA HOTTIP, humanRNA, Long NoncodingRNA, Small InterferingbioinformaticsdiagnosishaplotypeHCCHOTTIPmetastasismolecular dockingprognosissiRNASNPssurvival

Identifiers

PMID41828339
PMCPMC12984522

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.