Evidence mapPaperPMID 41828372Full record

ArticleInternational journal of molecular sciences2026

The Natural Triterpenoid Alisol B Overcomes Temozolomide Resistance in Glioblastoma Through Multi-Target Mechanisms: Coordinated Epigenetic, Metabolic, and Cell-Cycle Reprogramming.

Yamin Zhang, Bingfang Shen, Chaoqun Zhang, Ziting Li, Lisha Li, Xiaomei Xu, Hongwei Li, Wenjin Lin

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yamin ZhangFujian Key Laboratory of Medical Analysis, Fujian Academy of Medical Sciences, Fuzhou 350001, China.
Bingfang ShenCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Chaoqun ZhangCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Ziting LiCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Lisha LiFujian Key Laboratory of Medical Analysis, Fujian Academy of Medical Sciences, Fuzhou 350001, China.ORCID 0009-0006-3904-2154
Xiaomei XuFujian Key Laboratory of Medical Analysis, Fujian Academy of Medical Sciences, Fuzhou 350001, China.
Hongwei LiCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Wenjin LinFujian Key Laboratory of Medical Analysis, Fujian Academy of Medical Sciences, Fuzhou 350001, China.ORCID 0000-0002-4568-486X

Funding

Fujian Medical Innovation Project 2021CXA038Fujian Province Natural Science Foundation 2023J01173the Basic Special Project of Public Welfare Research Institutes in Fujian Province 2021R1012001
6 · The paper itself

Abstract

Glioblastoma (GBM) is a highly aggressive and therapy-resistant brain tumor, necessitating innovative multi-target strategies. Natural compounds like the triterpenoid Alisol B from Alisma orientale hold promise due to their polypharmacological potential, yet their system-level mechanisms are unclear. Using an integrated multi-omics approach (transcriptomics, proteomics, lysine acetyl-proteomics) in resistant GBM cells and validating findings in vitro and in AB strain zebrafish (

Indexed as

Brain NeoplasmsCholestenonesDrug Resistance, NeoplasmEpigenesis, GeneticGlioblastomaTriterpenesAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMetabolic ReprogrammingZebrafishCholestenonesTriterpenesAlisol Bepigenetic reprogrammingglioblastomametabolic reprogrammingmulti-target therapynatural productspolypharmacology

Identifiers

PMID41828372
PMCPMC12984972

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.