Evidence map›Paper›PMID 41828433›Full record

ArticleInternational journal of molecular sciences2026

Vitamin D Modulates Humoral Responses to SARS-CoV-2 Vaccination in Autoimmune Thyroiditis: An Endocrine-Immune Perspective Supported by Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations.

Nawel Zerouak, Salma Hentabli, Abderrahmane Zitouni, Mouna Lehassani, Hamza Hentabli, Mohamed Anis Haroun, Mammar Khames, Karine Benachour, Yassine Amrani, Mustapha Oumouna

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nawel ZerouakLaboratory of Biology and Experimental Pharmacology, Faculty of Sciences, Dr. Yahia Fares University, Medea 26000, Algeria.
Salma HentabliLaboratory of Biology and Experimental Pharmacology, Faculty of Sciences, Dr. Yahia Fares University, Medea 26000, Algeria.
Abderrahmane ZitouniLaboratory of Biology and Experimental Pharmacology, Faculty of Sciences, Dr. Yahia Fares University, Medea 26000, Algeria.
Mouna LehassaniLaboratory of Biology and Experimental Pharmacology, Faculty of Sciences, Dr. Yahia Fares University, Medea 26000, Algeria.
Hamza HentabliComputational Chemistry and Biophysics Group Drug Design, Department of Chemistry, University of Missouri-Columbia, Columbia, MI 65211, USA.
Mohamed Anis HarounLaboratory of Biology and Experimental Pharmacology, Faculty of Sciences, Dr. Yahia Fares University, Medea 26000, Algeria.
Mammar KhamesLaboratory of Biology and Experimental Pharmacology, Faculty of Sciences, Dr. Yahia Fares University, Medea 26000, Algeria.
Karine BenachourLaboratory of Biology and Experimental Pharmacology, Faculty of Sciences, Dr. Yahia Fares University, Medea 26000, Algeria.
Yassine AmraniDepartment of Respiratory Sciences, College of Life Sciences and NIHR Biomedical Research Centre (Respiratory Theme), Glenfield Hospital, Leicester LE1 7RH, UK.
Mustapha OumounaLaboratory of Biology and Experimental Pharmacology, Faculty of Sciences, Dr. Yahia Fares University, Medea 26000, Algeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune thyroiditis (AIT) is characterized by dysregulated endocrine-immune interactions, and vitamin D has been proposed as a potential immunomodulatory factor influencing vaccine-induced immune responses. This study investigated the association between serum vitamin D status and humoral responses to SARS-CoV-2 vaccination in patients with AIT, while exploring potential molecular mechanisms using network pharmacology, molecular docking and Molecular Dynamics (MD) simulations. Patients were stratified according to serum 25-hydroxyvitamin D levels as deficient, insufficient, or sufficient. Anti-spike receptor-binding domain (RBD) IgG titers, thyroid autoantibodies, and thyroid-stimulating hormone levels were measured. In parallel, vitamin D

Indexed as

COVID-19Immunity, HumoralSARS-CoV-2Thyroiditis, AutoimmuneVitamin DAdultAutoantibodiesFemaleHumansImmunoglobulin GMaleMiddle AgedMolecular Docking SimulationMolecular Dynamics SimulationVaccination25-hydroxyvitamin DAutoantibodiesImmunoglobulin GVitamin Dautoimmune endocrinologyautoimmune thyroiditisCOVID-19 vaccinationendocrine–immune crosstalkhumoral immune responsesmolecular dockingmolecular dynamicsnetwork pharmacologyvitamin D

Identifiers

PMID41828433
PMCPMC12985000

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.