Evidence map›Paper›PMID 41828463›Full record

ArticleInternational journal of molecular sciences2026

Neuroproteomic Profiling of the Anxiolytic Potential of

Lymelsie Aponte Ramos, Xandra Pena Díaz, Ricardo M Cruz Sánchez, Ana E Rodríguez De Jesús, Yadira M Cantres Rosario, Eduardo L Tosado Rodríguez, Abiel Roche Lima, Loyda M Meléndez, Ricardo Chiesa

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lymelsie Aponte RamosDepartment of Social Sciences, University of Puerto Rico at Cayey, Cayey 00737, Puerto Rico.
Xandra Pena DíazDepartment of Biology, University of Puerto Rico at Cayey, Cayey 00737, Puerto Rico.
Ricardo M Cruz SánchezDepartment of Biology, University of Puerto Rico at Cayey, Cayey 00737, Puerto Rico.ORCID 0000-0002-0256-8818
Ana E Rodríguez De JesúsTranslational Proteomics Center, Research Capacity Core, Center for Collaborative Research in Health Disparities, University of Puerto Rico-Medical Sciences Campus, San Juan 00921, Puerto Rico.
Yadira M Cantres RosarioTranslational Proteomics Center, Research Capacity Core, Center for Collaborative Research in Health Disparities, University of Puerto Rico-Medical Sciences Campus, San Juan 00921, Puerto Rico.
Eduardo L Tosado RodríguezIntegrated Informatics, Research Capacity Core, Center for Collaborative Research in Health Disparities, University of Puerto Rico-Medical Sciences Campus, San Juan 00921, Puerto Rico.ORCID 0000-0002-9140-8671
Abiel Roche LimaIntegrated Informatics, Research Capacity Core, Center for Collaborative Research in Health Disparities, University of Puerto Rico-Medical Sciences Campus, San Juan 00921, Puerto Rico.ORCID 0000-0003-2246-6744
Loyda M MeléndezTranslational Proteomics Center, Research Capacity Core, Center for Collaborative Research in Health Disparities, University of Puerto Rico-Medical Sciences Campus, San Juan 00921, Puerto Rico.ORCID 0000-0003-2571-8206
Ricardo ChiesaDepartment of Biology, University of Puerto Rico at Cayey, Cayey 00737, Puerto Rico.ORCID 0000-0002-2687-0456

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Carmen M Velez Vega · 2017 to 2026
$35.8M
National Institute of General Medical Sciences of the National Institutes of Health P20GM103475NIMHD NIH HHS U54MD007600
6 · The paper itself

Abstract

Anxiety disorders are the most prevalent mental health conditions worldwide, yet current treatments remain suboptimal, with benzodiazepines carrying risks of tolerance and dependence. These limitations motivate the search for novel anxiolytics. Tropical marine macroalgae represent a promising source of neuroactive metabolites. Here, we investigate the anxiolytic potential of

Indexed as

Anti-Anxiety AgentsDrosophila melanogasterProteomeProteomicsAnimalsSignal TransductionTandem Mass SpectrometryAnti-Anxiety AgentsProteomebehaviorDrosophila melanogastermarine algaeneuroproteomicsTandem Mass Tag (TMT) quantitative proteomics

Identifiers

PMID41828463
PMCPMC12984897

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.