In one paragraphReview in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Vinícius Rodrigues-SoaresLaboratory of Neuronal Physiology and Pathology, Department of Molecular and Cellular Biology, Institute of Biology, Fluminense Federal University, Niterói 24210240, RJ, Brazil.
Heitor Roque da CruzLaboratory of Neuronal Physiology and Pathology, Department of Molecular and Cellular Biology, Institute of Biology, Fluminense Federal University, Niterói 24210240, RJ, Brazil.ORCID 0009-0004-0732-0928 Gabriel Ferreira Dos SantosLaboratory of Neuronal Physiology and Pathology, Department of Molecular and Cellular Biology, Institute of Biology, Fluminense Federal University, Niterói 24210240, RJ, Brazil.
João Gabriel RestierLaboratory of Neuronal Physiology and Pathology, Department of Molecular and Cellular Biology, Institute of Biology, Fluminense Federal University, Niterói 24210240, RJ, Brazil.ORCID 0009-0009-4331-6930 Pedro CastilhoLaboratory of Neuronal Physiology and Pathology, Department of Molecular and Cellular Biology, Institute of Biology, Fluminense Federal University, Niterói 24210240, RJ, Brazil.
Natan Giovanni Ferreira Dos SantosLaboratory of Neuronal Physiology and Pathology, Department of Molecular and Cellular Biology, Institute of Biology, Fluminense Federal University, Niterói 24210240, RJ, Brazil.
Elias Avgerino Dos SantosLaboratory of Neuronal Physiology and Pathology, Department of Molecular and Cellular Biology, Institute of Biology, Fluminense Federal University, Niterói 24210240, RJ, Brazil.
Daniel Souza Monteiro de AraújoGraduate Program of Neurosciences, Institute of Biology, Fluminense Federal University, Niterói 24210201, RJ, Brazil.ORCID 0000-0003-1115-725X Karin da Costa CalazaGraduate Program of Neurosciences, Institute of Biology, Fluminense Federal University, Niterói 24210201, RJ, Brazil.ORCID 0000-0003-1199-1826 Rafael BritoLaboratory of Neuronal Physiology and Pathology, Department of Molecular and Cellular Biology, Institute of Biology, Fluminense Federal University, Niterói 24210240, RJ, Brazil.
Funding
Fellowships from the Coordination of Superior Level Staff Improvement (CAPES) postgraduation fellowshipsFoundation for Research Support of the State of Rio de Janeiro (FAPERJ) D.S.M.A. is supported by a special scholarship BCB-1 (315139/2025-0).Foundation for Research Support of the State of Rio de Janeiro (FAPERJ) K.C. Calaza (Grant E-26/211.289/2021)Foundation for Research Support of the State of Rio de Janeiro (FAPERJ) R.B. (Grant E-26/211.462/2019, E-26/210.410/2022).Foundation for Research Support of the State of Rio de Janeiro (FAPERJ) senior scientists of the Rio de Janeiro State (CNE/FAPERJ, Grant E-26/202.977/2017 and E-26/201.025/2021)National Council of Scientific and Technological Development (CNPq) KCC senior fellowship (304410/2019-5, 316553/2023-9)National Council of Scientific and Technological Development (CNPq) National Institute of Science and Technology-National Institute for Translational Neuroscience (INCT/INNT) (Grant 510 465346/2014-6)National Council of Scientific and Technological Development (CNPq) Programa Conhecimento Brasil - Atração e Fixação de Talentos (446463/2024-511 8)National Council of Scientific and Technological Development (CNPq) Universal (Grant 403325/2023-4)
6 · The paper itselfAbstract
Distinct molecular pathways of cell death drive the progression of neurological pathologies. Targeting the signaling cascades induced by oxidative stress and inflammation within these pathways is central to developing cytoprotective therapies against apoptosis, ferroptosis, and excitotoxicity. In recent years, the flavonoid icariin has emerged as a promising candidate, showing significant potential to intercept these specific cell death mechanisms. However, while the current literature highlights icariin's general neuroprotective effects, evidence regarding its precise interaction with distinct cell death modalities remains fragmented. This review synthesizes current knowledge to clarify the molecular logic by which icariin modulates these specific pathways in neurological models.
Indexed as
Cell DeathFlavonoidsNeurodegenerative DiseasesNeuroprotective AgentsAnimalsApoptosisHumansOxidative StressSignal TransductionFlavonoidsicariinNeuroprotective Agentscell deathicariinnatural productsneurodegeneration
Identifiers
PMID41828472
PMCPMC12984914
What Socratic holds
Textmetadata
LicenceCC BY
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