Evidence map›Paper›PMID 41828485›Full record

ArticleInternational journal of molecular sciences2026

Diagnostic Value of miR-21, miR-122, miR-145, and miR-146a in Acute Pancreatitis: Findings from the PASEVO Cohort in Southeastern Romania.

Diana Iosif, Costel Stelian Brînzan, Andra Iulia Suceveanu, Iulia Cîndea, Viorel Gherghina, Marius Dragoș Prăzaru, Alina Doina Nicoară, Felix Voinea, Miruna-Gabriela Vizireanu, Adrian Neluțu Mitroi and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Diana IosifDoctoral School of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.
Costel Stelian BrînzanCenter for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), "Ovidius" University, 900591 Constanta, Romania.ORCID 0000-0002-6944-3323
Andra Iulia SuceveanuFaculty of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.
Iulia CîndeaDepartment of Intensive Care Unit, St Andrew Apostle Emergency Hospital, 900591 Constanta, Romania.
Viorel GherghinaDepartment of Intensive Care Unit, St Andrew Apostle Emergency Hospital, 900591 Constanta, Romania.
Marius Dragoș PrăzaruDoctoral School of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.
Alina Doina NicoarăFaculty of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.ORCID 0000-0002-6702-7086
Felix VoineaFaculty of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.
Miruna-Gabriela VizireanuCenter for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), "Ovidius" University, 900591 Constanta, Romania.ORCID 0000-0001-7768-5114
Adrian Neluțu MitroiCenter for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), "Ovidius" University, 900591 Constanta, Romania.
Anca Florentina MitroiCenter for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), "Ovidius" University, 900591 Constanta, Romania.
Adrian Paul SuceveanuFaculty of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pancreatitis (AP) is an inflammatory condition of the pancreas that initiates a cascade of inflammation, which can cause pancreatic damage or spread to other organs. The severity of AP ranges from mild acute pancreatitis (MAP) to severe acute pancreatitis (SAP). While standard diagnostic tools include contrast-enhanced CT scans, clinical scoring systems like APACHE II and Ranson, and laboratory tests, miRNAs have emerged as crucial regulators of gene expression involved in various physiological and pathological processes. Over the last decade, research has demonstrated that significant alterations in miRNA levels are integral to AP development. Since one miRNA can target multiple genes, they serve as key modulators of disease progression.

Indexed as

MicroRNAsPancreatitisAcute DiseaseBiomarkersHumansRomaniaBiomarkersMicroRNAsMIRN146 microRNA, humanMIRN21 microRNA, humanacute pancreatitismicroRNAmiR-122miR-145miR-146amiR-21ROC analysisserum biomarkerssevere acute pancreatitis

Identifiers

PMID41828485
PMCPMC12984840

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.