Evidence map›Paper›PMID 41828519›Full record

ReviewInternational journal of molecular sciences2026

Oncometabolites and Hypoxia-Regulated Exosomes Shape HIF-Driven Macrophage Programs Across Type 2 Diabetes, Atherosclerosis, and Cancer.

Antonina Nowinka, Gabriela Krystek, Zuzanna Gontarek, Martyna Góralczyk, Antonina Waligórska, Marta Walenciak, Dorota Formanowicz

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Antonina NowinkaFaculty of Medicine, Poznan University of Medical Sciences, 60-812 Poznań, Poland.ORCID 0009-0000-1503-384X
Gabriela KrystekFaculty of Medicine, Poznan University of Medical Sciences, 60-812 Poznań, Poland.ORCID 0009-0005-4673-7184
Zuzanna GontarekFaculty of Medicine, Poznan University of Medical Sciences, 60-812 Poznań, Poland.ORCID 0009-0001-6840-7136
Martyna GóralczykFaculty of Medicine, Poznan University of Medical Sciences, 60-812 Poznań, Poland.ORCID 0009-0007-5364-2065
Antonina WaligórskaFaculty of Medicine, Poznan University of Medical Sciences, 60-812 Poznań, Poland.ORCID 0009-0009-5490-0796
Marta WalenciakFaculty of Medicine, Poznan University of Medical Sciences, 60-812 Poznań, Poland.ORCID 0009-0002-2702-2480
Dorota FormanowiczChair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Rokietnicka 8, 61-701 Poznań, Poland.ORCID 0000-0001-6691-3863

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncometabolites and hypoxia-regulated exosomes orchestrate hypoxia-inducible factor (HIF)-driven macrophage reprogramming across chronic cardiometabolic and oncologic conditions. In type 2 diabetes (T2D) and obesity, regional hypoxia in expanding white adipose tissue (WAT) reconfigures macrophage immunometabolism and chemokine signaling, recruits C-C chemokine receptor 2 (CCR2

Indexed as

AtherosclerosisDiabetes Mellitus, Type 2ExosomesHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMacrophagesNeoplasmsAnimalsHumansMetabolic ReprogrammingHypoxia-Inducible Factor 1, alpha SubunitatherosclerosisbelzutifanHIF-1αHIF-2αhypoxiahypoxia-regulated exosomeslactatemacrophage polarizationobesityoncometabolitesPD-L1PI3KγsuccinateTAMstumor microenvironmenttype 2 diabetes

Identifiers

PMID41828519
PMCPMC12984892

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.