Evidence map›Paper›PMID 41828536›Full record

ReviewInternational journal of molecular sciences2026

New Strategies for the Prevention and Therapy of Alzheimer's Disease Based on Stimulation of Brain Drainage and Lymphatic Clearance.

Oxana Semyachkina-Glushkovskaya, Vladislav Sursaev, Mikhail Poluektov, Sergey Diduk, Liubov Rychkova, Irina Madaeva, Liudmila Yakubova, Jürgen Kurths

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oxana Semyachkina-GlushkovskayaDepartment of Biology, Saratov State University, Astrakhanskaya 83 Str., 410012 Saratov, Russia.ORCID 0000-0001-6753-7513
Vladislav SursaevDepartment of Nervous Diseases and Neurosurgery, First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya 2, Building 4, 119435 Moscow, Russia.
Mikhail PoluektovDepartment of Nervous Diseases and Neurosurgery, First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya 2, Building 4, 119435 Moscow, Russia.ORCID 0000-0001-6215-0918
Sergey DidukDepartment of Biotechnology, Leeners LLC, 117186 Moscow, Russia.
Liubov RychkovaFederal State Budgetary Scientific Institution Scientific Centre for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia.
Irina MadaevaFederal State Budgetary Scientific Institution Scientific Centre for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia.
Liudmila YakubovaDepartment of General Medical Practice and Polyclinic Therapy, Grodno State Medical University, 230009 Grodno, Belarus.
Jürgen KurthsResearch Institute of Intelligent Complex Systems, Fudan University, 220 Handan Rd, Yangpu District, Shanghai 200437, China.ORCID 0000-0002-5926-4276

Funding

Russian Science Foundation 23-75-30001
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a serious medical challenge, representing an incurable and insidious disease. Current treatments can slow AD progression but cannot cure it. Promising new methods for AD therapy are essential for addressing the growing number of people with dementia, especially after the COVID-19 pandemic. The review highlights pioneering approaches to AD treatment based on innovative methods for the stimulation of brain drainage and clearance, in which the meningeal lymphatic vessels (MLVs) play a key role. Clinically promising noninvasive technologies using photobiomodulation for the effective clearance of metabolites, including amyloid beta (Aβ), and for the improvement of cognitive impairment during AD progression are discussed. An interesting part of the review is its analysis of innovative methods of improving the efficacy of anti-Aβ immunotherapy by stimulating MLV growth. The review is also focused on lifestyle, including sleep and physical exercises, discussing their support for the efficient lymphatic removal of waste products from the brain. Overall, the review provides an important, informative platform to excite the interest of a wide range of readers in the development of promising and clinically significant strategies for the treatment of AD, based on new strategies for the stimulation of brain drainage and clearance.

Indexed as

Alzheimer DiseaseBrainLymphatic VesselsAmyloid beta-PeptidesAnimalsCOVID-19HumansLow-Level Light TherapyAmyloid beta-PeptidesAlzheimer’s diseasebrain drainage and clearancedementiameningeal lymphatic vesselspharmacological methodsphotobiomodulationphysical exercisesleep

Identifiers

PMID41828536
PMCPMC12985885

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.