Evidence mapPaperPMID 41828588Full record

ReviewInternational journal of molecular sciences2026

Memory Cells in Atopic Dermatitis: Paving the Way to Disease Modification.

Raquel Dominguez-Lopez, Carlos J Aranda, Enrique Gómez-de la Fuente, Bibiana Pérez-García, Javier Perez-Bootello, Carlota Abbad-Jaime de Aragon, Álvaro González-Cantero, Emilio Berna-Rico

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Epithelial-Dermal Immune Memory: TrackingInternational journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raquel Dominguez-LopezDepartment of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitarian (IRYCIS), 28034 Madrid, Spain.ORCID 0009-0003-7230-402X
Carlos J ArandaDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain.ORCID 0000-0001-6224-9352
Enrique Gómez-de la FuenteDepartment of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitarian (IRYCIS), 28034 Madrid, Spain.
Bibiana Pérez-GarcíaDepartment of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitarian (IRYCIS), 28034 Madrid, Spain.
Javier Perez-BootelloDepartment of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitarian (IRYCIS), 28034 Madrid, Spain.ORCID 0009-0009-2253-5587
Carlota Abbad-Jaime de AragonDepartment of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitarian (IRYCIS), 28034 Madrid, Spain.ORCID 0000-0002-5587-1204
Álvaro González-CanteroDepartment of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitarian (IRYCIS), 28034 Madrid, Spain.
Emilio Berna-RicoDepartment of Dermatology, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitarian (IRYCIS), 28034 Madrid, Spain.ORCID 0000-0003-0348-5421

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease in which persistence of immunological memory underlies disease recurrence and progression toward atopic comorbidities. Evidence indicates that pathogenic tissue-resident memory T cells (TRM), including Th2- and Th22-skewed subsets, among others, persist in both lesional and clinically resolved skin and rapidly re-initiate inflammation through production of IL-4, IL-13, IL-22 and IL-31, promoting barrier dysfunction and pruritus. In parallel, circulating CLA

Indexed as

Dermatitis, AtopicImmunologic MemoryMemory T CellsAnimalsHumansSkinatopic dermatitisCLA+ memory T cellsdisease modificationepithelial alarminsimmunological memorymemory B cellsOX40/OX40L pathwaytissue-resident memory T cellstype 2 inflammation

Identifiers

PMID41828588
PMCPMC12985118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.