Zearalenone Induces Oxidative Stress and Apoptosis in the Jejunum of Weaned Piglets via the p53/Nrf2 Signaling Pathway.

Yihao Sang, Shaojin Hou, Zhongfang Zhang, Shuzhen Jiang, Weiren Yang, Qun Cheng

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

A Preliminary Study on the Effects of Low Doses of Purified Zearalenone in Weaned Female Piglets: A Multi-Organ Toxicity Investigation.Antioxidants (Basel, Switzerland) · 2026
Article

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5 · Who and what money

Authors and funding

6 authors.

Yihao SangDepartment of Animal Sciences and Technology, Qingdao Agricultural University, No. 700 Changcheng Street, Qingdao 266109, China.ORCID 0009-0003-5099-2570

Shaojin HouDepartment of Animal Sciences and Technology, Qingdao Agricultural University, No. 700 Changcheng Street, Qingdao 266109, China.

Zhongfang ZhangDepartment of Animal Sciences and Technology, Qingdao Agricultural University, No. 700 Changcheng Street, Qingdao 266109, China.

Shuzhen JiangDepartment of Animal Sciences and Technology, Shandong Agricultural University, No. 61 Daizong Street, Taian 271018, China.ORCID 0000-0002-4943-0322

Weiren YangDepartment of Animal Sciences and Technology, Shandong Agricultural University, No. 61 Daizong Street, Taian 271018, China.

Qun ChengDepartment of Animal Sciences and Technology, Qingdao Agricultural University, No. 700 Changcheng Street, Qingdao 266109, China.

Funding

he Natural Science Foundation of Shandong Province ZR2024MC124the Founding of Shandong Agriculture Research System in Shandong Province SDAIT-08-04 and SDAIT-08-05the Natural Science Foundation Youth Project of Shandong Province ZR2022QC030the Qingdao Agricultural University Doctoral Start-Up Fund XJ2023000401

6 · The paper itself

Abstract

This study investigated the mechanisms by which ZEA induces oxidative stress and apoptosis in the jejunum of piglets and explored the roles of the tumor suppressor gene p53 and nuclear factor E2-related factor 2 (Nrf2) signaling pathways. Twelve weaned piglets were randomized into Control (basal diet) and ZEA groups (basal diet + 1.0 mg/kg ZEA; 6 piglets/group). No differences were observed between the control and ZEA groups for all production performance indicators. Compared with the jejunum of the control group, the ZEA group exhibited reduced levels of total superoxide dismutase, glutathione peroxidase activity, and total antioxidant capacity, along with elevated malondialdehyde content. Morphological examination revealed increased crypt depth and decreased villus height and villus-to-crypt ratio, as well as swollen, vacuolated spherical mitochondria with disrupted cristae. Immunohistochemistry showed enhanced p53 and Nrf2 immunoreactivity. The relative mRNA levels of Nrf2, Ho1, Gpx1, Cytc1, p53, Caspase1, and Bax increased. The Bax/Bcl-2 ratio increased, and Keap1 and Bcl-2 mRNA levels decreased. The relative protein levels of Nrf2, p53, Bax, Caspase1, and Gpx1 increased, whereas that of Bcl-2 decreased. All differences were significant at

Indexed as

ApoptosisJejunumNF-E2-Related Factor 2Oxidative StressSignal TransductionTumor Suppressor Protein p53ZearalenoneAnimalsSwineWeaningNF-E2-Related Factor 2Tumor Suppressor Protein p53Zearalenoneapoptosisjejunumoxidative stressweaned pigletszearalenone

Identifiers

PMID41828618

DOI10.3390/ijms27052401

PMCPMC12985506

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.