Evidence mapPaperPMID 41828624Full record

ArticleInternational journal of molecular sciences2026

Association Between Personal, Behavioral, Psychological, Biochemical and Molecular Biomarkers with Illness Count in a Sample of Mexican Individuals.

Aniel Jessica Leticia Brambila-Tapia, Juan Manuel Ponce-Guarneros, Ana Míriam Saldaña-Cruz, Saúl Ramírez-De Los Santos, Heriberto Jacobo-Cuevas

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Aniel Jessica Leticia Brambila-TapiaDepartamento de Psicología Básica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-6455-3662
Juan Manuel Ponce-GuarnerosGroup of Assessment of Prognosis Biomarkers in Autoimmune Disorders, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-5035-3347
Ana Míriam Saldaña-CruzGroup of Assessment of Prognosis Biomarkers in Autoimmune Disorders, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-2272-9612
Saúl Ramírez-De Los SantosDepartamento de Psicología Básica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-7433-1908
Heriberto Jacobo-CuevasGroup of Assessment of Prognosis Biomarkers in Autoimmune Disorders, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-7813-7467

Funding

Universidad de Guadalajara PIN-2023-IV
6 · The paper itself

Abstract

The sum of diseases has been associated with many personal, behavioral, and psychological variables as well as with many biochemical, inflammatory, oxidative stress, and epigenetic biomarkers. However, the search for the association between some of these biomarkers and illness count is limited, particularly in Mexican individuals. (1) To determine the associations between personal, behavioral, biochemical, and molecular factors with the illness count in Mexican individuals, globally and segmented by sex, and (2) to determine the intercorrelation among the studied biomarkers. Mexican adults were invited to participate, and many personal, psychological, and biochemical variables were measured; in addition, the systolic blood pressure, body mass index, and waist-to-hip ratio were obtained. The self-report of 28 health conditions was measured, and the detection of 3 (diabetes, hypertension, and dyslipidemia) conditions was obtained with biochemical analyses and blood pressure measurement; with these reports, we obtained the variable illness count. A total of 157 individuals were included, of whom 83 (52.9%) were women; the median age and range were 24 (18-58) years old, and all participants were Mexican mestizo individuals. Women showed a higher number of self-reported/detected diseases than men. The multivariate analyses revealed that female sex, age, having children, risky eating behavior, poor sleep quality, systolic blood pressure, and lower levels of IL-10 were significantly correlated with the illness count. In the women's sample, lower levels of IL-10, less free time, monthly earnings, and depression were positively correlated with illness count. In the men's sample, the age, systolic blood pressure, poor sleep quality, 8-OHdG, IL-6, and plateletcrit, in addition to positive relations with others, were variables positively correlated with illness count. In the correlations of the studied biomarkers, we found that IL-10, TNF-α, and IL-8 showed a high positive correlation among them; in addition, inflammatory and oxidative stress biomarkers showed low significant correlations among them. Many personal, biochemical, and psychological factors are associated with the number of diseases, while the associated biomarkers differed in each sex, highlighting the role of IL-10, 8-OHdG, IL-6, and plateletcrit.

Indexed as

BiomarkersHypertensionAdolescentAdultBlood PressureBody Mass IndexDiabetes MellitusDyslipidemiasFemaleHumansMaleMexicoMiddle AgedOxidative StressSelf ReportYoung AdultBiomarkersbiochemical variablesbiomarkersillness countinflammationMexican individualsoxidative stresspsychological variables

Identifiers

PMID41828624
PMCPMC12985521

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.