ArticleInternational journal of molecular sciences2026
Extraction, Characterization, and Biological Evaluation of Atranorin Against Diabetes-Induced Reproductive Dysfunction Through Modulation of Oxidative Stress, Inflammatory Pathways and Key Reproductive Enzymes.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Evaluation of Betanin on Key Enzymes Related to Obesity, Diabetes, Insulin Signaling Pathway, and Metabolic Disorders: In Vitro, Cellular, and In Silico Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
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Authors and funding
7 authors.
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Abstract
Male fertility is declining worldwide, with notable reductions in sperm counts, emphasizing the need for new therapeutic interventions. Atranorin (ATR), a lichen-derived secondary metabolite, exhibits strong antioxidant and anti-inflammatory activities. This study assessed the protective effects of ATR on type 1 diabetes (T1D)-induced reproductive dysfunction in rats. T1D was induced in male Wistar rats via a single intraperitoneal injection of alloxan at 150 mg/kg body weight (bw). ATR significantly ameliorated T1D-related reproductive damage. At 170 mg/kg bw, ATR reduced hyperglycemia by 66% and attenuated seminal inflammation, decreasing leukocyte infiltration (-51%) and myeloperoxidase (MPO) activity (-68%). Oxidative balance improved, as evidenced by increased total antioxidant status (TAS) (+203%) and decreased thiobarbituric acid reactive substances (TBARS) (-73%), hydrogen peroxide (H
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