Evidence map›Paper›PMID 41828663›Full record

ArticleInternational journal of molecular sciences2026

Design and Multi-Level Biological Evaluation of Naphthyridine-Based Derivatives as Topoisomerase I/II-Targeted Anticancer Agents with Anti-Fowlpox Virus Activity Supported by In Silico Analysis.

Hagar S El-Hema, Hadeer M El Fekey, Adel A-H Abdel-Rahman, Alaa R I Morsy, Amina A Radwan, Eman S Nossier, Lama A Alshabani, Asmaa Saleh, Modather F Hussein, Mohamed A Hawata

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hagar S El-HemaBasic Science Department (Chemistry), Thebes Higher Institute for Engineering, Thebes Academy, Maadi 11434, Egypt.ORCID 0009-0000-3841-6122
Hadeer M El FekeyChemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt.
Adel A-H Abdel-RahmanChemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt.
Alaa R I MorsyCentral Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center, Cairo 11381, Egypt.
Amina A RadwanCentral Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center, Cairo 11381, Egypt.
Eman S NossierPharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.ORCID 0000-0001-6159-5333
Lama A AlshabaniDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0009-0004-5460-3330
Asmaa SalehDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0002-6286-319X
Modather F HusseinChemistry Department, College of Science, Jouf University, Sakaka 72341, Aljouf, Saudi Arabia.ORCID 0000-0003-3664-2745
Mohamed A HawataChemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt.

Funding

Princess Nourah bint Abdulrahman University Researchers PNURSP2026R940
6 · The paper itself

Abstract

Naphthyridine derivatives have emerged as privileged scaffolds with diverse pharmacological activities, particularly in anticancer and antiviral drug discovery. In this study, a series of naphthyridine-based derivatives (

Indexed as

Antineoplastic AgentsAntiviral AgentsDNA Topoisomerases, Type IDNA Topoisomerases, Type IIFowlpox virusNaphthyridinesTopoisomerase I InhibitorsAnimalsApoptosisCell Line, TumorCell ProliferationComputer SimulationDrug DesignHeLa CellsHumansMCF-7 CellsAntineoplastic AgentsAntiviral AgentsDNA Topoisomerases, Type IDNA Topoisomerases, Type IINaphthyridinesTopoisomerase I Inhibitorscaspase-9computational studiesfowl pox virusMCF-7 cellsnaphthyridinestopoisomerase I/IIwestern blot

Identifiers

PMID41828663
PMCPMC12986497

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.