Evidence map›Paper›PMID 41828668›Full record

ArticleInternational journal of molecular sciences2026

FSH Receptor Asn680Ser Polymorphism Modulates Intrafollicular Nitric Oxide Bioavailability and Ovarian Responsiveness During IVF.

Charalampos Voros, Diamantis Athanasiou, Despoina Mavrogianni, Ntilay Soyhan, Georgia Panagou, Maria Sakellariou, Georgios Papadimas, Fotios Chatzinikolaou, Eleni Sivylla Bikouvaraki, Georgios Daskalakis and 1 more

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Charalampos VorosFirst Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0000-0001-9477-7619
Diamantis AthanasiouFirst Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 106 79 Athens, Greece.
Despoina MavrogianniFirst Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0000-0003-1220-6594
Ntilay SoyhanIVF Athens Reproduction Center V.A., 151 23 Maroussi, Greece.
Georgia PanagouIVF Athens Reproduction Center V.A., 151 23 Maroussi, Greece.
Maria SakellariouIVF Athens Reproduction Center V.A., 151 23 Maroussi, Greece.ORCID 0000-0001-7538-6751
Georgios PapadimasFirst Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 106 79 Athens, Greece.
Fotios ChatzinikolaouFirst Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 106 79 Athens, Greece.
Eleni Sivylla BikouvarakiLaboratory of Cell and Gene Therapy, Biomedical Research Foundation of the Academy of Athens Greece (BRFAA), 115 27 Athens, Greece.
Georgios DaskalakisFirst Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0000-0001-7108-211X
Kalliopi PappaFirst Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0000-0002-1061-7405

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vitro fertilisation (IVF) has significant hurdles due to individual differences in ovarian response during controlled ovarian stimulation. The Asn680Ser polymorphism of the follicle-stimulating hormone receptor (FSHR) is linked to varying ovarian sensitivity to FSH. However, its relationship with intrafollicular redox signalling remains unclear. Nitric oxide (NO) is a crucial compound that functions inside follicles and participates in angiogenesis, steroidogenesis, and oocyte competence. This prospective observational research classified women undergoing IVF into Asn allele carriers (Asn/Asn and Asn/Ser) and Ser/Ser homozygotes, according to the FSHR Asn680Ser polymorphism. The groups were assessed according to follicular fluid nitric oxide metabolites (NO

Indexed as

Fertilization in VitroNitric OxideOvarian FolliclePolymorphism, Single NucleotideReceptors, FSHAdultFemaleFollicular FluidHumansOvaryOvulation InductionFSHR protein, humanNitric OxideReceptors, FSHAsn680Ser polymorphismFSH receptorinfertilityIVFnitric oxide

Identifiers

PMID41828668
PMCPMC12985945

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.