Evidence mapPaperPMID 41828690Full record

ArticleInternational journal of molecular sciences2026

Multidomain Biomarkers as Predictors of Cardiovascular Risk in Acute Coronary Syndrome: A Prospective Evaluation.

Guadalupe Estela Gavilánez-Chávez, Maria G Zavala-Cerna, Sandra Guzmán-Silahua, Luz Rebeca Rodríguez-Rivera, Cristo F Urzua-Ortega, Ernesto Germán Cardona-Muñoz, Eduardo Chuquiure-Valenzuela, Benjamín Rubio-Jurado, Arnulfo Hernán Nava-Zavala

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guadalupe Estela Gavilánez-ChávezServicio de Urgencias, Hospital General Regional 46, Instituto Mexicano del Seguro Social, Guadalajara 44910, Mexico.
Maria G Zavala-CernaLaboratorio de Investigación en Inmunología, Decanato Medicina, Universidad Autónoma de Guadalajara, Zapopan 45129, Mexico.ORCID 0000-0001-6508-9657
Sandra Guzmán-SilahuaUnidad de Investigación Epidemiológica y en Servicios de Salud, Centro Medico Nacional de Occidente, Órgano de Operación Administrativa DesconcentradaJalisco, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico.ORCID 0000-0002-8751-2994
Luz Rebeca Rodríguez-RiveraServicio de Urgencias, Hospital General Regional 46, Instituto Mexicano del Seguro Social, Guadalajara 44910, Mexico.
Cristo F Urzua-OrtegaLaboratorio de Investigación en Inmunología, Decanato Medicina, Universidad Autónoma de Guadalajara, Zapopan 45129, Mexico.
Ernesto Germán Cardona-MuñozPrograma de Doctorado en Farmacología, Departamento de Fisiología, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Eduardo Chuquiure-ValenzuelaInstituto Nacional de Cardiológia "Ignacio Chavez", Ciudad de Mexico 14080, Mexico.ORCID 0000-0003-4812-1090
Benjamín Rubio-JuradoUnidad de Investigación Epidemiológica y en Servicios de Salud, Centro Medico Nacional de Occidente, Órgano de Operación Administrativa DesconcentradaJalisco, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico.ORCID 0000-0002-5138-8063
Arnulfo Hernán Nava-ZavalaUnidad de Investigación Epidemiológica y en Servicios de Salud, Centro Medico Nacional de Occidente, Órgano de Operación Administrativa DesconcentradaJalisco, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico.ORCID 0000-0003-3061-521X

Funding

Mexican Social Security Institute FIS/IMSS/PROT/MD19/1892
6 · The paper itself

Abstract

Acute coronary syndrome (ACS), driven by inflammation and thrombosis, remains a leading cause of morbidity globally. While traditional risk scores are useful, the prognostic value of combining inflammatory and autoimmune biomarkers remains understudied. This study aimed to evaluate the predictive role of high-sensitivity C-reactive protein (hs-CRP), platelet factor 4 (PF4), D-dimer, and antiphospholipid antibodies (anticardiolipin and anti-β2-glycoprotein I) for the development of major adverse cardiovascular events (MACE) in patients with ACS. We conducted a prospective cohort study at a tertiary referral center in Mexico. A total of 103 patients admitted with confirmed ACS were included. Blood samples were collected upon admission to measure biomarker levels. Participants were followed for 30 days. The primary outcome was the occurrence of MACE, defined as reinfarction, death, percutaneous coronary intervention, or bypass surgery. Multivariate logistic regression analysis was performed to identify independent predictors, adjusting for age, smoking, and comorbidities. MACE occurred in 51.4% of participants. Patients with adverse outcomes were significantly older and had longer hospital stays (

Indexed as

Acute Coronary SyndromeBiomarkersAgedC-Reactive ProteinFemaleFibrin Fibrinogen Degradation ProductsHeart Disease Risk FactorsHumansMaleMiddle AgedPlatelet Factor 4PrognosisProspective StudiesRisk FactorsBiomarkersC-Reactive ProteinFibrin Fibrinogen Degradation Productsfibrin fragment DPlatelet Factor 4acute coronary syndromeautoimmunitybiomarkersMACE

Identifiers

PMID41828690
PMCPMC12985923

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.