Evidence map›Paper›PMID 41828696›Full record

ArticleInternational journal of molecular sciences2026

Clonal Dynamics of FLT3-ITD from Diagnosis to Relapse: Ultra-Sensitive Patient-Specific Monitoring by ddPCR.

Alessandro Ferrando, Johanna Umurungi, Alice Costanza Danzero, Antonio Frolli, Rita Vacca, Arianna Savi, Giovanni Fornari, Valentina Gaidano, Alessandro Cignetti, Beatrice Sani and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alessandro FerrandoDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.ORCID 0009-0000-6304-9782
Johanna UmurungiDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.ORCID 0009-0006-1483-4171
Alice Costanza DanzeroDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.ORCID 0009-0007-8657-1187
Antonio FrolliDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.
Rita VaccaDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.
Arianna SaviDivision of Hematology, AO Ordine Mauriziano di Torino, 10128 Turin, Italy.
Giovanni FornariDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.
Valentina GaidanoDivision of Hematology, AO Ordine Mauriziano di Torino, 10128 Turin, Italy.ORCID 0000-0003-0701-7975
Alessandro CignettiDivision of Hematology, AO Ordine Mauriziano di Torino, 10128 Turin, Italy.ORCID 0000-0003-2109-1194
Beatrice SaniDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.ORCID 0009-0004-1437-7201
Simone RoccoDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.ORCID 0000-0001-8805-959X
Barbara PergolizziDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.ORCID 0000-0003-4686-0068
Carmen FavaDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.ORCID 0000-0002-4896-981X
Cristina PanuzzoDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.
Jessica PetitiDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.ORCID 0000-0001-8640-2462
Daniela CilloniDepartment of Clinical and Biological Sciences, University of Turin, AOU San Luigi Gonzaga, Orbassano, 10043 Turin, Italy.ORCID 0000-0001-6346-4791

Funding

Astellas Pharma SPA ISR005958
6 · The paper itself

Abstract

The FLT3-ITD mutation is a critical prognostic marker in acute myeloid leukemia (AML) and recent clinical trials demonstrate that FLT3-based measurable residual disease (MRD) is both prognostic and predictive, guiding therapeutic interventions in intensive and post-transplant settings. Conventional detection methods lack the sensitivity required for effective MRD monitoring. We developed a patient-specific droplet digital PCR (ddPCR) approach achieving analytical sensitivity of 10

Indexed as

fms-Like Tyrosine Kinase 3Leukemia, Myeloid, AcutePolymerase Chain ReactionHumansMutationNeoplasm, ResidualRecurrenceFLT3 protein, humanfms-Like Tyrosine Kinase 3AMLclonal dynamicddPCRFLT3-ITDMRD

Identifiers

PMID41828696
PMCPMC12985544

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.