Evidence map›Paper›PMID 41828702›Full record

ArticleInternational journal of molecular sciences2026

Molecular Lung Imaging Following Exposure to Radiation Predicts Long-Term Survival in Rats.

Anne V Clough, Kathrina Mpala, Pardis Taheri, Laura Norwood Toro, Andreas M Beyer, Tracy Gasperetti, Ming Zhao, Sarah Kerns, Heather A Himburg, Said H Audi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anne V CloughDepartment of Mathematical and Statistical Sciences, Marquette University, Milwaukee, WI 53233, USA.
Kathrina MpalaDepartment of Biomedical Engineering, Medical College of Wisconsin, Marquette University, Milwaukee, WI 53233, USA.
Pardis TaheriDepartment of Biomedical Engineering, Medical College of Wisconsin, Marquette University, Milwaukee, WI 53233, USA.
Laura Norwood ToroDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Andreas M BeyerDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Tracy GasperettiDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Ming ZhaoDepartment of Medicine (Cardiology), Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Sarah KernsDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-6503-0011
Heather A HimburgDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-9676-6371
Said H AudiClement J. Zablocki V.A. Medical Center, Milwaukee, WI 53295, USA.ORCID 0000-0002-4887-604X

Funding

SPECT Imaging and Computational Modeling for Assessment of Acute Lung InjuryR15HL129209 · NHLBI · MARQUETTE UNIVERSITY · PI SAID H AUDI · 2015 to 2026
$1.8M
National Heart Lung and Blood Institute 2R15HL129209-03National Heart Lung and Blood Institute R01HL152712National Heart Lung and Blood Institute R01HL173549National Institute of Allergy and Infectious Diseases U01AI186939National Institute of Allergy and Infectious Diseases U19AI067773NHLBI NIH HHS R15 HL129209VA BX001681
6 · The paper itself

Abstract

Delayed effects of acute radiation exposure (DEARE), including radiation pneumonitis (lung-DEARE), develop weeks to months after radiation exposure. Pathway-targeted biomarkers that capture early oxidative stress and cell death could improve risk stratification and provide objective measures of mitigator efficacy. The objective was to test whether molecular lung imaging predicts long-term survival and mitigator response after irradiation. Rats received 13.5 Gy leg-out partial-body irradiation with a subset treated with the radiation-injury mitigator lisinopril. Rats underwent lung imaging at weeks 2 and 4 post-irradiation with

Indexed as

LungMolecular ImagingRadiation Injuries, ExperimentalRadiation PneumonitisAnimalsBacteriocinsBiomarkersLisinoprilMaleOrganotechnetium CompoundsOxidative StressRadiation ExposureRatsBacteriocinsBiomarkersLisinoprilOrganotechnetium Compoundstechnetium 99m HYNIC-duramycin99mTc-duramycin99mTc-HMPAOlisinoprilmitochondrial DAMPsoxidative stresspartial-body irradiationradiation pneumonitisSPECT imaging

Identifiers

PMID41828702
PMCPMC12986413

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.