Evidence map›Paper›PMID 41828782›Full record

ReviewMolecules (Basel, Switzerland)2026

Enhanced Bioavailability and Health Benefits of Blueberry Anthocyanins: An Updated Review on Mechanisms and Approaches.

Rabia Ramzan, Zafarullah Muhammad, Adnan Amjad, Hafiz Rizwan Sharif, Guoqiang Zhang, Ana Chen

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rabia RamzanCollege of Biological and Food Engineering, Anhui Polytechnic University, Wuhu 241000, China.
Zafarullah MuhammadCollege of Biological and Food Engineering, Anhui Polytechnic University, Wuhu 241000, China.
Adnan AmjadFaculty of Food Science and Nutrition, Bahauddin Zakariya University, Multan 60000, Pakistan.
Hafiz Rizwan SharifInstitute of Food Science and Nutrition, University of Sargodha, Sargodha 40100, Pakistan.
Guoqiang ZhangCollege of Biological and Food Engineering, Anhui Polytechnic University, Wuhu 241000, China.
Ana ChenCollege of Biological and Food Engineering, Anhui Polytechnic University, Wuhu 241000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blueberries are highly valued for their nutritional content, primarily due to their high anthocyanin content, which is the principal bioactive compound contributing to their health-enhancing properties. Extensive research has established that blueberry anthocyanins exhibit significant antioxidant activity and confer various health benefits, including anti-cardiovascular, anti-diabetic, anti-inflammatory, and anticancer effects, as well as enhancements in cognitive function and visual acuity. Nonetheless, the chemical instability of anthocyanins, influenced by environmental factors such as temperature, light, oxygen, pH, and enzymatic activity, presents a substantial challenge for their effective application, leading to reduced stability, limited bioavailability, and decreased efficacy in functional foods and nutraceuticals. Using a defined search strategy focused on recent advances, this review synthesizes the chemical structures, biological activities, and health benefits of blueberry anthocyanins and critically examines strategies to improve their stability and bioavailability, including nanoparticulate systems, microencapsulation, based on delivery systems like protein, polysaccharides, liposomes, multiple emulsions, and composite delivery systems. Additionally, this review underscores the current research status and translational prospects for the industrial application of blueberry anthocyanins while also considering key scalability issues, including carrier regulation, sensory effects, and shelf-life stability. Developing practical approaches to enhance anthocyanin stability and bioavailability is crucial for maximizing their therapeutic potential and advancing the use of blueberries as functional foods.

Indexed as

AnthocyaninsBlueberry PlantsAnimalsAntioxidantsBiological AvailabilityHumansAnthocyaninsAntioxidantsbioavailability mechanismblueberry anthocyaninshealth potentialsinfluencing factorsstability improvement

Identifiers

PMID41828782
PMCPMC12985910

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.