Novel NTA-Ni

Min Zhao, Chen Liang, Boheng Liu, Ahsan Javed, Ran Zhou, Xiaozhen Diao, Chuanyun Ren, Wenhui Wu

Abstract read

In one paragraph

Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Min ZhaoDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

Chen LiangDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

Boheng LiuDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

Ahsan JavedDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0002-6930-1958

Ran ZhouDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

Xiaozhen DiaoDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0003-1805-5408

Chuanyun RenMa Xiaoxu (Shanghai) Biotechnology Co., Ltd., Shanghai 201502, China.

Wenhui WuDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0002-1710-8582

Funding

the National Natural Science Foundation of China No.82173731the Scientific Research Project of Shanghai International Science and Technology Cooperation Fund Project No. 17490742500

6 · The paper itself

Abstract

The design and optimization of immobilized metal affinity chromatography (IMAC) media are crucial to enhancing the purification efficiency of recombinant proteins. In this study, the agarose-based microspheres are prepared by using a three-factorial Box-Behnken design followed by NTA-Ni

Indexed as

immobilised metal affinity chromatographyNTA-Ni2+ agarose-based microspheresprotein purificationresponse surface method

Identifiers

PMID41829263

DOI10.3390/polym18050566

PMCPMC12987016

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.