ReviewPolymers2026
Biodegradable Polymeric Core/Shell Nanoformulations Encapsulating Essential Oils: Physicochemical Design, Controlled Release, and Targeted Acne and Sebum Management.
Review in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review examines biodegradable polymer-based core-shell nanoformulations encapsulating essential oils for acne treatment through the lens of physicochemical design and controlled delivery mechanisms. Acne is a common inflammatory skin disorder closely associated with sebum overproduction and microbial imbalance, while conventional therapies, although effective, may present long-term side effects. Increasing attention has therefore turned to sustainable dermatological materials derived from eco-friendly polymers combined with naturally active compounds. Recent advances show that core-shell nanostructures fabricated from biodegradable polymers function as physicochemically engineered carriers for volatile essential oils. They enhance their stability and protect them from premature degradation. They also enable controlled release governed by diffusion, polymer relaxation, interfacial interactions, and degradation kinetics. This review highlights how polymer chemistry, interfacial properties, particle morphology, and processing routes determine encapsulation efficiency, release profiles, and skin permeation behaviour. Particular emphasis is placed on structure-property-function relationships, including mass transport phenomena, thermodynamic compatibility between polymers and essential oils, surface charge, wettability, and nanostructure architecture, which collectively influence bioavailability and therapeutic performance. By integrating concepts from polymer physical chemistry, colloid and interface science, and drug delivery kinetics, these sustainable nanoformulations emerge as promising platforms for acne and sebum control. Overall, essential oil-loaded biodegradable polymeric core-shell systems represent a sustainable and scientifically grounded approach to acne management, although further physicochemical characterization, in vivo validation, and consideration of cost, technical challenges, and current limitations are required to support clinical translation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.